In: Biology
Why might a small deletion be viable if heterozygous?
How does a small duplication result in a phenotype when heterozygous?
Larger deletions are typically not viable even as heterozygotes. Why? And what genetic term is associated with this phenomenon?
Answer:
Why might a small deletion be viable if heterozygous?
How does a small duplication result in a phenotype when heterozygous?
Duplication of certain genetic elements may act as mutations.and elicit new phenotypes.Duplications can cause doubling of chromosomal segments (or increase in copy number of a particular chromosomal region) and result in the formation of unpaired loops. One example of a small duplication in heterozygous resulting in a new phenotype is bar shaped eye in Drosophila present in flies heterozygous for a duplicated gene.
Larger deletions are typically not viable even as heterozygotes. Why? And what genetic term is associated with this phenomenon?
A large Heterozygous deletion causes a hemizygous (only one copy present) state in a gene and this could be lethal since regions that are crucial for functioning are affected.