Question

dehydrated patients may be given physiological buffered saline(PBS) solution with a pH of about 7.4 intravenously to restore their fluid balance. does it only include sodium chloride in the PBS solution? if not, why?

Answer 1

Question: does it only include sodium chloride in the PBS solution? if not, why?

Answer:    NO, it does not only include sodium chloride in the PBS solution but also includes H₂PO₄^- / HPO₄^2-buffer to mimic physiological condional pH. The recipe/procedure is as follows.

Phosphate buffered saline (PBS) is a buffer solution. It is a water-based salt solution containing disodium hydrogen phosphate (Na₂HPO₄), sodium chloride (NaCl) and, in some formulations, potassium chloride (KCl) and potassium dihydrogen phosphate (KH₂PO₄). The most common composition of PBS (simple concentration):

NaCl .......8 g/L

KCl .........0.2 g/L

Na₂HPO₄.......1.44 g/L

KH₂PO₄........0.24 g/L

We have to adjust the pH to 7.4 with HCl. and add distilled water to a total volume of 1 liter.

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