Question

In: Biology

Why are the mutations K65R and D113E, both causing drug resistance such a surprise, whereas, the...

Why are the mutations K65R and D113E, both causing drug resistance such a surprise, whereas, the mutations Q151M and Q151N are not such a surprise. Explain the reasoning behind this. The answer to this question is not found in the paper, but based on what you now understand about mutations in general

Solutions

Expert Solution

The Question is about drug resistance in HIV virus REVERSE TRANSCRIPTASE enzyme. The genetic material in HIV virus is RNA. To incorporate it's genetic material into host genetic material which is DNA ,it should be converted first into DNA from RNA.Reverse transcriptase do this work for virsuv

To tackle with HIV virus drugs have been synthesised against RT ENZYME .

Drugs binds to specific residues of the RT enzyme at specific sites.usualy drugs binds to the sites which are vital for enzyme activity i.e substrate binding site , polymerization site ,Rnase H site etc.

Mutation in the residues which are important for drug binding, can reduce binding of the drug to RT enzyme.

IN the above given mutation K65R (lysin to arginine) and D113E (aspartate to glutamate) are important sites for drug bind and mutation here will inhibit drug binding and HIV virus become resistant from the drug .

In mutation Q151M and Q151N ,binding assays has been done so far shows that these mutation doesnot halt drug binding ,drug binding inhibition canolny occur with mutation at other residues as well with this.


Related Solutions

Germline mutations occur in sperm or egg and are heritable, whereas somatic mutations occur in non-germ...
Germline mutations occur in sperm or egg and are heritable, whereas somatic mutations occur in non-germ cells and are not heritable. Imagine that you are working in a laboratory which is studying on tissue/cell specific mutation pattern. You have all the tools (such as cell culture, imaging, sequencing etc.) and materials (such as genomic DNA, tissue and primary fibroblast cells from a human individuals). By using a NGS analysis please set up experiments/pipeline, including which method/algorithm would you use to...
In lab you are going to be using drosophila flies with sepia mutations (SE, se) causing...
In lab you are going to be using drosophila flies with sepia mutations (SE, se) causing brown eyes found on chromosome 3 and apterous mutation (AP, ap) on chromosome 2 causing loss of wings. These are recessive mutations. Red eye is the wild-type phenotype. Assuming you have a female heterozygous at both loci. Draw the chromosomes as they go through meiosis (Make sure you show somatic cell, prophase I, metaphase I, metaphase II, gametes.) Draw all possible gametes. What percentage...
6. Two common sources of emerging diseases are mutations in disease-causing organisms that enable them to...
6. Two common sources of emerging diseases are mutations in disease-causing organisms that enable them to transfer from one host species to another, and invasions of disease-causing organisms into new ecosystems. a. Briefly describe one example of each, ensuring you clearly label which is an example of invasion and which is transfer across species b. Describe what is meant by the term antimicrobial resistance c. Use one of the examples you gave in part a) to describe how the rate...
How can a patient develop resistance to a chemotherapy drug? Describe the different mechanisms of drug...
How can a patient develop resistance to a chemotherapy drug? Describe the different mechanisms of drug resistance?
What is ARAMCO? Why are low yields on its bonds a surprise?
What is ARAMCO? Why are low yields on its bonds a surprise?
Why are tumor suppressor gene mutations recessive while oncogene mutations are dominant?
Why are tumor suppressor gene mutations recessive while oncogene mutations are dominant?
The locomotion of fibroblasts in culture is immediately halted by the drug cytochalasin, whereas colchicine causes...
The locomotion of fibroblasts in culture is immediately halted by the drug cytochalasin, whereas colchicine causes fibroblast to cease to move directionally and to begin extending lamellipodia in seemingly random directions.inkection of anti-vimentin has no obvious effect on fibroblast migration.what do these results suggest about the role of the cytoskeleton in fibroblast movement?
The locomotion of fibroblasts in culture is immediately halted by the drug cytochalasin, whereas colchicine causes...
The locomotion of fibroblasts in culture is immediately halted by the drug cytochalasin, whereas colchicine causes fibroblasts to cease to move directionally and to begin extending lamellipodia in seemingly random directions. Injection of anti-vimentin has no obvious effect on fibroblast migration. What do these results suggest about the role of the cytoskeleton in fibroblast movement?                                              
Discuss mechanisms by which gene expression may be altered. How do these alterations induce cancer-causing mutations...
Discuss mechanisms by which gene expression may be altered. How do these alterations induce cancer-causing mutations in cell DNA?
Antibiotic resistance in bacteria occurs because ___. Group of answer choices antibiotic exposure triggers mutations in...
Antibiotic resistance in bacteria occurs because ___. Group of answer choices antibiotic exposure triggers mutations in bacteria human cells become immune to the effects of the antibiotics over time bacteria mutate in order to become resistant antibiotic use kills bacteria which are not resistant, leaving resistant bacteria to reproduce
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT