Question

What is the relationship between the amount of DNA condensation and the level of transcription?

Answer 1

Answer:

Relationship between the amount of DNA condensation and the level of transcription:

• The condensation of chromosomes occur during mitosis and cell division. The degree of chromatin condensation varies with the cell cycle and the chromatin is structurally loose during interphase to promote replication and transcription process.
• Transcription requires the binding of the transcription factors to DNA and binding of RNA polymerase to promoter region. The degree of DNA condensation can affect the level of transcription by affecting the ability of these proteins and regulatory molecules to bind to DNA.
• DNA accessibility for transcription is an important criteria for efficient transcription and if the DNA is too tightly packed or loosely packed, the levels of transcription will be affected.
• So, a dynamic balance between effective DNA packaging/condensation and and accessibility of transcription factors and other important proteins is critical for an efficient transcription.