In: Biology
In Drosophila, the X-linked recessive mutation vermillion (v) causes bright red eyes, in contrast to the brick-red eyes caused by the wild-type allele. A separate autosomal recessive mutation, brown (bw), causes flies to have brown eyes. Flies with both mutations have no eye pigmentation and are white-eyed. Determine the F1 and F2 phenotypic ratios for each sex from the following crosses:
(a) vermillion females X brown males
(b) wild-type females X white-eyed males
Answer=if we have one X-linked & one autosomal then it is easier to treat the two genes separately & combine the results at the end.
(a) vermillion females X brown males
for vermillion,
v is female is =XvXv
male= X+Y
parent= vermillion females X brown males
genotypes = XvXv X X+ Y
gametes= Xv Xv X+ Y
F1 generation= XvX+ XvX+ XvY XvY
=(female) (female) (male) (male)
all F1 females are XvX+ & all males are XvY
brown +b X +b
both produce + & b gametes which combine to produce ++ +b b+ & bb
Now combine
F2 females will be 1/2X +Xv X 1/4 ++ = 1/8 X+Xv++ normal wild type eyes
and 1/2 X+Xv X 1/2 +b =1/4X+Xv+b normal wild type eyes .
finally
1/2X+Xv X 1/4bb = 1/8 brown eyes.
then 1/2 XvXv X1/4 ++ = 1/8XvXv++ vermillion eyes: 1/2 XvXv X1/2b+ =1/4XvXv+b vermillion eyes and 1/2XvXv X1/4 bb =1/8 V =XvXvbb white eyes.
F2 females 1/2 X+Y X 3/4 ++ or +b =3/8 X+Y++/X+Yb+ brown eyes,1/2X+Y X 1/4bb= 1/8 X+Ybb brown eyes.
1/2XvY X3/4 ++/+b =3/8 XvY++ or +b vermillion eyes and 1/2 XvY X 1/4bb =1/8 XvYbb white eyes.
(b) wild-type females X white-eyed males