Question

27. Which of the following statements is not true concerning protein folding? a. Proteins fold around a hydrophobic core b. The interior of proteins is held together exclusively by hydrophobic interactions c. The amino acid sequence of a protein is responsible for determining the shape of a protein d. The active conformation of a protein is it most thermodynamically favorable state e. none of the above

Answer 1

Here the answer will be (e)none of the above.

All statements are true for protein folding.Proteins have several layers of structure each of which is important in the process of protein folding. The first most basic level if this structure is the sequence of amino acids themselves.  it will determine the types of interactions seen in the protein as it is folding.The interactions of the amino acids will determine what the secondary and tertiary structure of the protein will be.

The next layer in protein structure is the secondary structure. The secondary structure includes architectural structures that extend in one dimension.This is important because it leads to a more thermodynamically stable conformation and leads to less strain on the protein as a whole and thus are aided by the conformation.

The tertiary structure is the next layer in protein structure. This takes the α-Helixes and β-sheets and allows them to fold into a three dimensional structure.Most proteins take on a globular structure once folded.

The globular proteins generally have a hydrophobic core surrounded by a hydrophilic outer layer. These interactions are important because they lead to the global structure and help create channels and binding sites for enzymes.

Hope this will help.