Question

Which statements are true regarding protein transport into peroxisomes?

Choose one or more:

Like mitochondrial proteins, some peroxisomal proteins arrive via vesicles that bud from the ER.

Like proteins transported into mitochondria, proteins can enter the peroxisome in a folded conformation.

Like prospective nuclear proteins, some peroxisomal proteins are recognized by receptor proteins in the cytosol.

Like proteins destined for the ER, nucleus, or mitochondria, peroxisomal proteins bear a distinct signal sequence.

Like proteins transported into the nucleus, proteins must unfold before entering the peroxisome.

Like mitochondria, peroxisomes contain translocators through which proteins enter the organelle.

Answer 1

Tracfficking of proteins into the peroxisomes take place in multiple ways, broadly depending on whether they are are targeted to its matrix or its membrane.

For transportation into the matrix, the protein binds to a receptor in the cytosol itself which carries it to the peroxisosme where it docks to a specific receptor. The protein is then handed over to a carrier protein, residing in the plasma membrane, transport the protein in the peroxisome.

For transportation to the peroxisomal matrix, one may either employ a direct method or an indirect one. The former involves a peroxisome target sequence (PTS) on the protein allow them to bind to species proteins in the memebrane surface of peroxisomes which in turn help the protein to get integrated into the peroxisomal membrane.

The latter involves chaperone to get proteins at the peroxisomal memebrane where they get integrated. Therefore the correct options are : A, B, C, D and F