Question

Compare and conntrast negative feedback control of an enzyme versus enzyme repression.

Answer 1

Negative feedback control of enzyme	Enzyme repression
Negative feedback control or feedback ihibition takes place where multiple enzymes act upon a single metabolic cascade in which end product or product from the reaction from any of the later stages binds with the enzyme/s of upper level of the cascade to regulate the amount/concentration of the final product of the cascade.	Enzymatic repression is a procedure to decrease any enzymatic activity by decreasing its synthesis with the help of repressor molecule.
This kind of inhibition does not occur in the genetic level.	Repression occur in genetic level because allosteric regulatory repressor molecule binds with the promoter of a enzyme coding gene sequence and blocks transcription.
Total concentration of enzyme remains unchanged but its catalytic activity reduces.	concentration of enzyme decreases.
Example: Succinyl CoA negetively inhibiting -ketoglutarate dehydrogenase complex in TCA cycle	Example: lac operon