“Rate enhancement” of a chemical reaction by an enzyme compares which of the following values? a....

“Rate enhancement” of a chemical reaction by an enzyme compares which of the following values?

a. kforward vs. kreverse

b. k without enzyme and kcat with enzyme

c. kcat/KM without enzyme and kcat/KM with enzyme

d. Vmax without enzyme and Km with enzyme

e. kcat with enzyme and kdiffusion

Expert Solution

C- kcat/KM without enzyme and kcat/KM with enzyme

Enzymatic rate enhancements arise from the unmatched ability of enzymes to stabilise the transition states of the reactions that they catalyse. Comparison of rate constants of an enzyme‐catalysed reactions, that is, kcat and kcat/Km, to that of the corresponding reaction in the absence of the enzyme, that is, kN, provides quantitative measures of enzyme catalytic power. Moreover, the ratio of kN to kcat/Km provides a quantitative measure of transition state stabilisation effected by enzymes, which in turn motivates the development of ultrapotent transition state analogue enzyme inhibitor.

queen_honey_blossom answered 2 years ago

The rate of a chemical reaction is not dependent on which of the following parameters. the...

The rate of a chemical reaction is not dependent on which of the following parameters. the balanced equation for the reaction temperature orientation of molecules during collisions presence or absence of a catalyst concentration of reactants involved in the rate-determining step. energy of activation

1. When an enzyme runs a chemical reaction, what happens to the enzyme at the end...

1. When an enzyme runs a chemical reaction, what happens to the enzyme at the end of the reaction? a) it is unchanged, and can run another reaction b) it is weakened, and is slower the next time c) it becomes part of the product, and is used up d) it is permanently damaged, or destroyed 2. When an enzyme accelerates a reaction rate, what does the enzyme do, thermodynamically (energy-wise)? a)lowers the activation energy for the reaction b) allows...

An enzyme is discovered that catalyzes the chemical reaction SAD --> <-- HAPPY A team of...

An enzyme is discovered that catalyzes the chemical reaction SAD --> <-- HAPPY A team of motivated researchers set out to study the enzyme, which they call happyase. Under a constant enzyme concentration, [E] of 2.0 uM, they studied the relationship between substrate concentration [SAD] and reaction velocity V0. Their data is shown below: [SAD] (uM) V0 (uMs-1) 20 3.4 x 103 40 5.4 x 103 60 6.6 x 103 80 7.4 x 103 Can you...

The following reaction rate data are collected upon analysis of an enzyme catalyzed hydrolysis. The reaction...

The following reaction rate data are collected upon analysis of an enzyme catalyzed hydrolysis. The reaction is carried out with two diﬀerent inhibitors. Determine the modes of inhibition for each inhibitor. (The rates provided are relative to the rate measured in the absence of inhibitor. The enzyme concentration for each set of data is equal.) No inhibitor [S]0 (10−2 M) 1.25 3.84 5.81 7.13 v0 0.398 0.669 0.859 1.000 [I1]– –2mmol/L [S]0 (10−2 M) 1.25 2.5 4.00 5.50 v0 0.179...

25) Am enzyme-catalyzed reaction proceeds at a faster rate than an uncatalyzed reaction because the enzyme...

25) Am enzyme-catalyzed reaction proceeds at a faster rate than an uncatalyzed reaction because the enzyme lowers the difference in free energy between the reactants and the products. a. True b. False

Describe the kinetic differences between an uncatalyzed second order chemical reaction and an enzyme catalyzed reaction.

Answer the following question 1. Does the amount of enzyme influence the rate of reaction ?...

Answer the following question 1. Does the amount of enzyme influence the rate of reaction ? 2. Does the temperature of the solution influence activity of enzyme ? 3. Boiling an enzyme before a reaction does not influence its activity. ( is this correct and why ?) 4. The pH of the solution does not influence the activity of an enzyme ( is this correct and why?)

3. What happens to the enzyme and the substrate during a chemical reaction? What does it...

3. What happens to the enzyme and the substrate during a chemical reaction? What does it mean by enzymes being “specific”? Why is the active site specific for only one type of substrate? Please type the answer. Thanks

The following data were obtained for the concentration vs. time for a certain chemical reaction. Values...

The following data were obtained for the concentration vs. time for a certain chemical reaction. Values were measured at 1.0 s intervals, beginning at 0.00 and ending at 20.0 s. Concentrations in mM are: 10.00, 6.91, 4.98, 4.32, 3.55, 3.21, 2.61 2.50, 2.22, 1.91, 1.80, 1.65, 1.52, 1.36 1.42, 1.23, 1.20, 1.13, 1.09, 1.00, 0.92 a) Plot concentration, c, vs. time, t, ln c vs. t, and 1/c vs. t. b) Decide whether the data best fit zero-order, first-order or...

An enzyme catalyzes the reaction S → P. The table shows how the reaction rate (v)...

An enzyme catalyzes the reaction S → P. The table shows how the reaction rate (v) of the enzyme varies with the substrate concentration [S]. 0,0500 0,04545 0,0250 0,03448 0,0167 0,02778 0,0125 0,02326 0,0100 0,02000 a) Create a Lineweaver-Burk plot of the data given in the table above. b) Calculate Km, Vm, and Vm / Kmfor the enzyme. c) Also calculate kcat and kcat / Km (the specificity constant) when given that [E] = 10 nM.d) How saturated will an...

Question