Question

In your own words, describe three mechanisms of transcriptional regulation, as discussed in this course, that are involved in controlling the rate of expression of hydrolytic enzymes associated with lysosomes. For each mechanism described, include whether the rate of expression would be increased or decreased.

Answer 1

Answer:

• Transcriptionalregulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.
• In a hypothetical example, the factors A and B might regulate a distinct set of genes from the combination of factors A and C.
• Phenomenon of genomic imprinting, whatever its biological functions and evolutionary origins may be, ultimately manifests itself in the monoallelic expression of certain genes.
• The assumption has been, therefore, that the transcriptional regulatory systems of imprinted genes would directly or indirectly represent the principal focus of the imprinting process.
• As this chapter will discuss, however, our perceptions of gene regulation mechanisms are currently undergoing a radical re-evaluation and some of the emerging concepts may prove to be of importance to our understanding of how genomic imprinting functions.
• Transcriptional repression in cancer can also occur by other epigenetic mechanisms, such as altered expression of microRNAs. In breast

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