Are repressors and inducers enzymes?

# pre-transcriptional control

Are repressors and inducers enzymes? I was looking into how repression actually blocks RNA Polymerase, but how does induction happen?

Expert Solution

1. Repressor - a repressor is not enzyme but it is DNA binding protein coded by operon to which it inhibits. Repressor has ability to bind with operator and blocks RNA polymerase binding to promoter. Generally repressor binds to noncoding regulatory region of operon and this sequence is near to promoter so that RNA polymerase cannot bind to promoter. As mRNA is not synthesized by binding repressor to operator, protein is not synthesized. So that repressor inhibits gene expression.

2. Inducer - an inducer is not enzyme but it is also protein and has binding site on repressor. When inducer binds to repressor, repressor gets inactivated by conformational change caused by inducer and due to this change repressor no longer can bind with operator. Repressor leaves the operator and then RNA polymerase binds to promoter and transcription strats. In this way inducer initiates gene expression by inactivating repressor molecule.

gladiator answered 2 years ago

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