Question

Which of the following does not occur during muscle fiber maturation?

a. Myoblast cells align through expression of fibronectin and cadherins

b. Myoblast are induced to undergo mitosis by FGF signaling

c. Myotime cells are induced to become myoblast through juxtracrine signaling from the neural tube

d. Myoblasts fuse into myotubes

Answer 1

The statement - Myotome cells are induced to become myoblast through juxtracrine signaling from the neural tube does not occur during muscle fiber maturation. During muscle fibre maturation, the myotome cells are activated by various proteins such as MyoD and Myf5 which induce its differentiation into the myoblasts. All the other statements occur in the muscle fiber maturation.

For further studies you can read the following research articles:

1. Vaz, R., Martins, G.G., Thorsteinsdóttir, S. et al. Fibronectin promotes migration, alignment and fusion in an in vitro myoblast cell model. Cell Tissue Res 348, 569–578 (2012). https://doi.org/10.1007/s00441-012-1364-1

2. Conte, C., Ainaoui, N., Delluc-Clavières, A., Khoury, M. P., Azar, R., Pujol, F., Martineau, Y., Pyronnet, S., & Prats, A. C. (2009). Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism. Nucleic acids research, 37(16), 5267–5278. https://doi.org/10.1093/nar/gkp550

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