There have been a number of studies indicating that schizophrenia is a complex genetic disorder. Which...

There have been a number of studies indicating that schizophrenia is a complex genetic disorder. Which of the following observations are most consistent with this hypothesis? (select two answers)

Siblings of individuals with schizophrenia have an elevated risk of developing schizophrenia.

In monozygotic twins, if one twin has schizophrenia, it is very rare that the other is affected.

Malnutrition in utero and certain infections may increase risk of schizophrenia.

Schizophrenia follows an autosomal recessive inheritance pattern.

Expert Solution

Schizophrenia is a disorder of the brain that is caused by genetic and environmental factors. Schizophrenic patients have abnormal social behavior and they can not think clearly, and they fail to understand reality. Schizophrenia is a complex disorder. Siblings of individuals with schizophrenia have an elevated risk of developing schizophrenia. In monozygotic twins, if one twin has schizophrenia, then there is a 30-50% chance that the other twin will also have schizophrenia. Malnutrition in utero and certain infections (especially viral) increase the risk of schizophrenia. Schizophrenia is a multi-factorial disorder. Many genes are involved in the disorder and hence the disorder is not due to one dominant or recessive gene. So schizophrenia does not follow an autosomal recessive inheritance pattern. So, the correct options are option A, and C, Siblings of individuals with schizophrenia have an elevated risk of schizophrenia, malnutrition in utero and certain infections may increase risk of schizophrenia.

gladiator answered 1 year ago

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