1) The client is to receive 250 mg of cefazolin, IM, every 12 hours. The directions...

1) The client is to receive 250 mg of cefazolin, IM, every 12 hours. The directions for reconstitution of cefazolin for injection are on the drug label in the form of a table. Directions read: “Use 2 mL sterile water as a diluent. Resulting solution contains approximately 125 mg/mL, with an approximate available volume of 2 mL.” What is the final concentration of the prepared cefazolin solution for IM administration?

2) The physician orders Penicillin G Sodium 500,000 units. The vial of powder is labeled 5,000,000 units. Directions on the label read: Add 3mL diluent to provide 1,000,000 units/mL

Expert Solution

No.1.

The client is to receive 250 mg of cefazolin, IM, every 12 hours

The directions for the reconstitution of cefazolin for injection is "Use 2 mL sterile water as a diluent".

The resulting solution contains approximately 125 mg/mL, with an approximate available volume of 2 mL.

So 2 ml will contain 250 mg of the drug (according to 125 mg/ml)

Answer - 2 ml is the final concentration of the prepared cefazolin solution for IM administration.

No.2.

order dose Penicillin G Sodium 500,000 units

The vial of powder is labeled 5,000,000 units

Dilution instruction says, " Add 3mL diluent to provide 1,000,000 units/mL"

Here 1 ml = 1,000,000 units

So,

Answer - The client needs 0.5 ml.

Nightingale answered 2 years ago

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