Question

In: Biology

Imagine a human protein containing 27 repeats of a simple domain arranged in tandem. In contrast...

Imagine a human protein containing 27 repeats of a simple domain arranged in tandem. In contrast a homolog found in bacteria contain only one domain. what is the minimum number of duplication events that can account for the evolution of this protein since our divergence from bacteria? write down the number

Solutions

Expert Solution

Answer:

Based on the given information:

  • Number of repeats of single domain arranged in tandem contained in human protein = 27
  • Number of repeats of single domain in homolog Bacteria = 1
  • Minimum number of duplication events that can account for the evolution of this protein since our divergence from bacteria = 5

Explanation:

DNA Duplication can exponentially expand the block and can lead to the generation of tandem repeated arrays.

For example, in this case, number of duplication events to generate 27 repeats of an original DNA segment that encodes a protein domain can be determined as below:

  • If number of duplication events are 4 = 24 = 16 repeats (which is less than the 27 repeats of a simple domain in human protein), so number of duplication events will be more than this.
  • If number of duplication events are 5 = 25 = 32 (which covers 27 repeats of a simple domain in human protein). Therefore, a minimum of 5 duplication events can account for the evolution of this protein since our divergence from bacteria. The actual number of duplication events can be more than five duplication.

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