Why is a protein more soluble when the pH is greater than or less than its pI?

Expert Solution

It is positively charged at low pH and negatively charged at high pH. ... In general, the net charge on the protein, either positive or negative, can interact with water molecules, meaning that it is more likely for a protein molecule to dissociate itself from other protein molecules, thus, more soluble.

It is positively charged at low pH and negatively charged at high pH. The intermediate pH at which a protein molecule has a net charge of zero is called the isoelectric point of that protein. ... As a result, amino acid is the least soluble when the pH of the solution is at its isoelectric point.

queen_honey_blossom answered 2 years ago

Will the pH of the following compounds be less than 7, greater than 7, or approximately...

Will the pH of the following compounds be less than 7, greater than 7, or approximately equal to 7? A) ammonium iodide B) barium nitrite C) barium bromide D) ammonium chloride

Which of the following slightly soluble compounds has a solubility greater than that calculated from its...

Which of the following slightly soluble compounds has a solubility greater than that calculated from its solubility product because of hydrolysis of the anion present: AgCl, BaSO4, CaF2, Hg2I2, MnCO3, ZnS, PbS?

why Bradford method is more accurate than UV method when measure the concentration of protein?

prove that 2/pi is less than or equal to (sinx)/x which is less than or equal...

prove that 2/pi is less than or equal to (sinx)/x which is less than or equal to 1. for x is in (0,pi/2]

solve tan^2 x =1 where x is more than or equal to 0 but x is less than or equal to pi

solev tan^2 x =1 where x is more than or equal to 0 but x is less than or equal to pi

Silver chromate is more soluble in solutions containing some (less than 1 M) potassium nitrate, even...

Silver chromate is more soluble in solutions containing some (less than 1 M) potassium nitrate, even though neither potassium nor nitrate show up in the BCE for the dissolution reaction Ag2CrO4 (s) ↔ 2 Ag+(aq) + CrO4 2-(aq) The solubility product constant (which is not the same as the solubility!) for silver chromate is Ksp = 1.1 x 10-12 making it a pretty insoluble substance. Your job is to figure out the molar solubility in pure water, then the molar...

Biochemistry: If a protein has a pI of 7, what pH should the buffer in the...

Biochemistry: If a protein has a pI of 7, what pH should the buffer in the S column be to ensure that the protein binds to the resin?

Why is acetylsalicylic acid even less soluble in water than salicylic acid? What kind of reaction...

Why is acetylsalicylic acid even less soluble in water than salicylic acid? What kind of reaction is the conversion of methyl salicylate to salicylic acid and why? What is added or taken away? What kind of reaction is the conversion of salicylic acid to acetylsalicylic acid and why? What is being added or taken away?

For each of the following, fill in the blanks with "Less than", "Greater than", or "Equal...

For each of the following, fill in the blanks with "Less than", "Greater than", or "Equal to" *) A gas flows through a one-inlet, one-exit control volume operating at steady state with no internal irreversibilities, Qcv = 0. Heat transfer at a rate Qcv takes place only at a location on the boundary where the temperature is Tb. The specific entropy of the gas at the exit is _____ than the specific entropy of the gas at the inlet. *)...

. [No commas – hint: there is no answer greater than +$999.9, nor less than -$999.9.]...

. [No commas – hint: there is no answer greater than +$999.9, nor less than -$999.9.] All answers are in billions of dollars so there is no need to write that out. For the following five questions, assume the following characteristics of the monetary transmission mechanism: The money multiplier is 3.25 Interest rates will change by 2.5% for every $45 billion change in the money supply. Investment will change by $76 billion for every 1.5% change in the interest rate....

Question