Which reactions of glycolysis are coupled to ATP hydrolysis? Which reactions involve substrate-level phosphorylation? Which reactions...

Which reactions of glycolysis are coupled to ATP hydrolysis? Which reactions involve substrate-level phosphorylation? Which reactions depend on either fermentation or aerobic respiration to continue?

Expert Solution

The first reaction of glycolysis that is conversion of glucose to glucose 6-phosphate and third step that is conversion of fructose 6-phosphate to fructose 1,6-biphosphate are coupled to ATP hydrolysis. These steps consume ATP and produces ADP through hydrolysis. These ateps are also known as energy investment phase.

The reactions of glycolysis that is conversion of 1,3-Biphosphoglycerate to 3-phosphoglycerate and conversion of phosphoenolpyruvate to pyruvate are the best example of substrate level phosphorylation, since ATP is synthesized from the substrate without the involvement of electron transport chain.

The last step of flycolysis that is conversion of pyruvate to either CO₂ and H₂O or lactate depends on the fermentation or aerobic respiration. Lactate is formed from pyruvate under anaerobic condition. In the aerobic condition, pyruvate is oxidized to CO₂ and H₂O.

gladiator answered 2 years ago

The ATP that is generated in glycolysis is produced by substrate-level phosphorylation

ATP synthesis in glycolysis substrate-level phosphorylation The ATP that is generated in glycolysis is produced by substrate-level phosphorylation, a very different mechanism than the one used to produce ATP during oxidative phosphorylation. Phosphorylation reactions involve the addition of a phosphate group to another molecule. Sort the statements into the appropriate bin depending on whether or not they correctly describe some aspect of substrate-level phosphorylation in glycolysis.

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