Hemophilia is a disease caused by a recessive allele on the X chromosome. Use a Punnett...

Hemophilia is a disease caused by a recessive allele on the X chromosome. Use a Punnett square to help describe the offspring phenotypes from the cross: heterozygous female crossed to male with hemophilia.

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Expert Solution

Hemophilia: It is a rare disorder in which there is a lack of sufficient blood-clotting proteins (clotting factors) which affect the clotting of blood, abnormal clotting of blood. Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The gene responsible is present on the X chromosome. If the male have affected mother then there re 100% chance of having he disorder.

Let the allele for the hemophilia disorder is H.

It is a recessive disorder so express only when present on both the chromosomes.

Let,

XX - Female
XY - Male
X^HX^H - Affected Female
X^HX - Carrier Female
X^HY - Affected male

According to the question the cross between heterozygous female crossed to male with hemophilia.

Heterozygous female - X^HX
male with hemophilia - X^HY

Cross: X^HX * X^HY

The gametes produce from X^HX female are X^H and X.
The gametes produce from X^HY female are X^H and Y.

Punnett square for the cross:

Gametes	X^H	X
X^H	X^HX^H	X^HX
Y	X^HY	XY

Thus, 50% of the offspring has chance of getting the disorder.

25 % chance of not having the disorder.
25 % chance of being unaffected.
50% chance of affected female
50% chance of affected son.

X^HX^{H -} Affected daughter

X^HX - Carrier daughter

X^HY - Affected son

XY - Unaffected son

Thank you!

gladiator answered 1 year ago

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