Question

What is the likely scenario that will happen if the Oxygen Transfer Rate in the reactor is smaller than the Oxygen Uptake Rate (e.g. what will happen to your cells, doubling time and so on)?

Answer 1

In aerobic bioprocesses, oxygen is a key substrate; because of its low dissolvability in stocks (fluid arrangements), a constant supply is required. The oxygen exchange rate (OTR) must be known, and if conceivable anticipated to accomplish an ideal outline operation and scale-up of bioreactors. Numerous investigations have been directed to improve the proficiency of oxygen exchange. The disintegrated oxygen fixation in a suspension of aerobic microorganisms relies upon the rate of oxygen exchange from the gas stage to the fluid, on the rate at which oxygen is transported into the cells (where it is devoured), and on the oxygen take-up rate (OUR) by the microorganism for development, upkeep and generation. The gas-fluid mass move in a bioprocess is unequivocally impacted by the hydrodynamic conditions in the bioreactors. These conditions are known to be a function of energy dispersal that relies upon the operational conditions, the physicochemical properties of the way of life, the geometrical parameters of the bioreactor and furthermore on the nearness of oxygen devouring cells. Mixed tank and air pocket section (of different sorts) bioreactors are generally utilized as a part of a vast assortment of bioprocesses, (for example, aerobic maturation and organic wastewater medicines, among others). Blended tanks bioreactors give high estimations of mass and warmth exchange rates and astounding blending. In these frameworks, a high number of factors influence the mass exchange and blending, yet the most critical among them are stirrer speed, sort and number of stirrers and gas stream rate utilized. In bubble segments and airdrops, the low-shear condition contrasted with the mixed tanks has empowered effective development of shear delicate and filamentous cells. Oxygen exchange is regularly the rate-constraining advance in the aerobic bioprocess because of the low solvency of oxygen in the medium. The right estimation or potentially forecast of the volumetric mass exchange coefficient, (k(L)a), is a urgent advance in the plan, operation and scale-up of bioreactors.