Compare and contrast GPCR signaling and enzyme-coupled signaling. Focus on the general mechanism of these signaling...

Compare and contrast GPCR signaling and enzyme-coupled signaling. Focus on the general mechanism of these signaling pathways.

Expert Solution

Ans) 1) The enzyme linked coupled receptor has intrinsic tyrosine kinase which will autophosphorylate the tyrosine residues which then serves as a binding site for Grb2 protein wheras GPCR do not have such intrinsic tyrosine kinase associated.

2) In receptor tyrosine pathway, PKB (protein kinase B) is activated by PIP3 kinase. PKB can also be activated by IRS-1.Then the activated PKB will activate AKT kinase which inturn activate BAD protein which causes apoptosis.Wheras in GPCR pathway, PKA (protein kinase A) is activated by cAMP which activate CREB (cAMP response element binding protein) which enters nucleus to turn ON the cell cycle. PKC (Protein kinase C) can also get activated by the DAG (diacylglycerol).

Similarities between both of these pathways is that after the primary ligand binding,the conformational change occurs in the receptor. Another similarity is that both of these pathways can turn ON the cell cycle.

gladiator answered 1 year ago

Compare and contrast the action of epinephrine vs glucagon binding and signaling from its target GPCR...

Compare and contrast the action of epinephrine vs glucagon binding and signaling from its target GPCR in order to regulate glucose metabolism under stress vs rest conditions.

Explain what specific signaling information processing happens in the case of GPCR (G protein Coupled Receptors).

Describe how activation or synthesis occurs in the follow steps in the GPCR signaling pathway. GPCR...

Describe how activation or synthesis occurs in the follow steps in the GPCR signaling pathway. GPCR and G protein signal molecule and GPCR protein kinase A and cAMP protein kinase A and other protein kinases adenylyl cyclase and cAMP

Compare and contrast in details human capital and signaling models.

Briefly describe two key differences that contrast signaling between receptor tyrosine kinases (RTKs) and G-protein coupled...

Briefly describe two key differences that contrast signaling between receptor tyrosine kinases (RTKs) and G-protein coupled receptors (GPCRs).

Compare and contrast the mechanism of action of sulfonamides and fluoroquinolones and their therapeutics applications ?

Explain in detail how coupled enzyme assay works

Looking for a SHORT, CLEAR, AND SIMPLE answer: Compare and contrast signaling by neurons, which secret...

Looking for a SHORT, CLEAR, AND SIMPLE answer: Compare and contrast signaling by neurons, which secret neurotransmitters at synapses, with signaling carried out by endocrine cells, which secrete hormones into the blood. Discuss the relative advantages of the two mechanisms

Compare and contrast transduction (general and specific), transformation, and transfection

Compare and contrast using 2 two model organisms: a) the major signaling pathways, mechanisms and roles...

Compare and contrast using 2 two model organisms: a) the major signaling pathways, mechanisms and roles of genes that give rise to left-right asymmetry in vertebrates.b) Describe how some major organs are affected by L-R asymmetry in both your model organisms?

Question