Question

Please explain the following disorders. Must be more than 100 words.

Autoimmune

Alloimmune

Drug-induced

Answer 1

AUTOIMMUNE : refers to a misdirected immune system where the immune mechanisms attacks body's own cells and tissues leading to organ damage. Autoimmune cells are normally eliminated by the immune self tolerance mechanisms of the human body. Different theories were proposed to explain the phenomenon of autoimmunity such as Clonal deletion theory, Clonal anergy theory and idiotype network theory. Most common autoimmune diseases are SLE, Rheumatoid Arthritis, Sjogren syndrome, HSP, Wegners Granulomatosis etc:

ALLOIMMUNE

is an immune response directed against non self antigens from organisms belonging to same species. Examples include histocompatibility antigens and Blood group antigens. Graft rejection and Blood transfusion reactions are the result of alloimmunity.

Drug Induced

Drug induced diseases are due to the effect of specific drugs. Various side effects can be Idiosyncratic or dose related . These reactions lead to poor compliance and drug cessation. Various disorders are drug induced lupus, Aplastic anemia, immunodeficiency, seizures etc: These usually imorove With cessation of the dyu6