if you could obtain embryos of an early tetrapod such as Panderichthys, what experiment would you...

if you could obtain embryos of an early tetrapod such as Panderichthys, what experiment would you carry out to investigate the molecular basis of the fin-to-limb transition?

Expert Solution

Acquisition of a new control region for HOX gene expression could have driven fin to limb transition. Regulatory regions of Hox a and Hox d cluster regulate the expression of Hox gene. experiment on mice show that in tatrapods enhancer on the telomeric side or 3' side derive the proximal expression and patterning of thid part of limb ( humerous radius ulna). Enhancer on the centromeric side or 5' end drive Hox gene expression involved in patterning of distal part of limb.

In fins, 5' and 3' enhancers interact in the same way with fish Hox cluster genes as enhancer on tatrapods and derive expression in different proxodistal region of fin.

when tested in mice, both the enhancers of fish drive only expression in proximal region.

when tested in coelacanth, 5' region contains a new enhancer that is also present in tatrapods but not in teloosts. This hyphothesize that acquisItion of this enhancer and subsequent further changes in regulatory region led to the transition from fin to limb.

gladiator answered 1 year ago

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if you could obtain embryos of an early tetrapod such as Panderichthys, what experiment would you...

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