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In: Biology

Put the following in order with respect to Antibody-Dependent Enhancement Cytokine release and wide scale inflammatory...

  1. Put the following in order with respect to Antibody-Dependent Enhancement

    Cytokine release and wide scale inflammatory response

    Antibody binds weakly to epitope on pathogen   

    Antigenic Drift Occurs

    Immune cell infection   

    Fc region of antibody binds to FcR on immune cell

Solutions

Expert Solution

Answer

(c) Antigenic drift ----> (b) Antibody binds weakly to epitome on pathogen --->. (e). Fc region of Antibody binds to FcR on immune cell --->. (d). Immune cell infection. ---> (a) Cytokine release and wide scale immune response.

Explanation :

Antibody dependent enhancement is a phenomenon in which a virus binds to a non -neutralizing antibodies.This enhances the entry of virus into host immune cell and leads to more infectivity and virulence.

This whole process starts with a small change in the genetic make up of a viral strain ( called Antigenic drift ).

The viruses bind to antigen binding site of the Antibody which is incapable to neutralize it because of the antigenic drift. The Fc receptor present on the immune cell attached this Antibody to which the antigen (virus ) is attached. Thus the virus gains entry inside the immune cell and a wide scale immune response with release of Cytokine is initiated.

gladiator answered 1 year ago
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