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The recommended dose for the antifungal agent Ancobon is 50 to 150mg/kg/day administered q6h (every 6...

The recommended dose for the antifungal agent Ancobon is 50 to 150mg/kg/day administered q6h (every 6 hours. It is available in 250 mg capsules. A patient weighs 162 lbs. (5pts)

What is the range in mg the patient could take per dose?
What is the range in number of capsules the patient could take per dose?

Expert Solution

Recommended dose is 50 to 150 mg/kg/day every 6 hours

Weight of patient in kg is 73.5kg

To find range -

If in 1kg dose recommended is 50mg /day

Then in 73.5 kg dose recommended is 50× 73.5 = 3675mg /day

If in 24 hours (1 day) dose is 3675

Then in every 6 hours dose will be = 3675× 6/24 = 918.75mg in one dose ( round off will be 919mg per dose)

Also if in 1kg dose recommended is 150mg/day

Then in 73.5kg dose recommended is = 150×73.5 = 11025 mg /day

If in 24 hours dose is 11025mg /day for this patient

Then in every 6hours dose is = 11025 ×6/24 =

2756.25 mg/ dose ( round off is 2756 mg)

Thus the range in mg patient could take per dose = 919 - 2756 mg /dose or 918.75 - 2756.25 mg/dose

b) if 1 tablet contains = 250 mg or

250 mg drug is in 1 tablet , then

In 918.75mg drug is in = 1×918.75/ 250 = 3.6 ( 3 and half tablets)

Also if 250 mg drug is in 1 tablet

Then in 2756.25 mg drug number of tablets will be = 1 × 2756.25/ 250 = 11 tablets

Thus range of tablets per dose for patient will be 3 and half tablets to 11 tablets.

Please Upvote if you find it satisfactory. Comment if any doubt.

Nightingale answered 2 years ago

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