This is a very simpllistic approach to protein folding, which ignores solvent and volume effects, but it allows us to practice what we have learned about thermodynamics and kinetics. Enzymes are long chains of amino acids that have to fold in the proper way so as to exhibit enzyme activity. They can catalyze certain reactions. Let us pick a reaction in the human body at 37 C, we will call it enzyme X.

Let's say that enzyme X is the catalyst responsible for breaking starch down to individual glucose molecules. What of the following things can happen to the starch and enzyme system if you rainse the temperature?

a-the rate of the reaction of starch going to glucose will increase

b-nothing should happen since a catalyst does not affect the equilibrium

c-the enzyme could stop working effectively becauset the folded form would stop being made and would start to unravel if the process is reversible

d-the equilibrium constant will get bigger to favor the glucose side more

A quantity of 2.30 × 102 mL of 0.900 M HNO3 is mixed with 2.30 × 102 mL of 0.450 M Ba(OH)2 in a constant-pressure calorimeter of negligible heat capacity. The initial temperature of both solutions is the same at 18.46°C. The heat of neutralization when 1.00 mol of HNO3 reacts with 0.500 mol Ba(OH)2 is −56.2 kJ/mol. Assume that the densities and specific heats of the solution are the same as for water (1.00 g/mL and 4.184 J/g · °C, respectively). What is the final temperature of the solution? (in C)

please answer all or explain.

11. Circle the statement that is not true for hemoglobin.

A.The R-state has a high affinity for diatomic oxygen.

B. 2,3-bisphosphoglycerate stabilizes the T-state.

C. Carbon monoxide stabilizes the R-state.

D. H⁺ ions stabilize the R-state.

12. Circle the statement that is not true for CO₂.

A. It is a non-polar molecule that can diffuse across cell membranes.

B. It can combine with terminal amines on proteins to form carbamates.

C. It is primarily transported in the blood as HCO₃.

D. It inhibits the release of O₂ from hemoglobin.

13. What environmental pressure is considered responsible for keeping the sickle cell gene in the human gene pool?

14. Circle the statement that is not true for an enzyme.

A. It reduces ΔG for a reaction.

B. It stabilizes the transition state in a reaction.

C. It increases the reaction rate in both the forward and reverse directions.

D. It has a catalytic site that is a crevice or cleft in the molecule.

15. What are the two types of cofactors that interact with enzyme? (8 points)

Enough of a monoprotic acid is dissolved in water to produce a 0.0129 M solution. The pH of the resulting solution is 2.69. Calculate the Ka for the acid.

how much 5.60 M NaOH must be added to a 420.0 ml of a buffer that is 0.0205 M acetic acid and 0.0245 M sodium acetate to raise the pH to 5.75?

Please explain in detail the mechanisims by which these biologicals work on a patient with NSCLC?

A) Gefitinib aka Iressa

B) Erlotinib aka Tarceva

C) Afatinib aka Giotrif

Piperazine, HN(C4H8)NH, is a diprotic weak base used as a corrosion inhibitor and an insecticide and has the following properties: pKb1=4.22pKb2=8.67 For writing the reactions of this base in water, it can be helpful to abbreviate the formula as Pip: Pip+H2OPipH++H2O⇌⇌PipH++OH−PipH22++OH− The piperazine used commercially is a hexahydrate with the formula C4H10N2⋅6H2O.

Show the titration curve by plotting the following points:

• the initial pH of the solution. (pH=11.23)

• the pH at the 25% neutralization point of the first neutralization (pH=10.26)

• the pH at the 50%neutralization point of the first neutralization. (pH=9.78)

• the pH at the 75% neutralization point of the first neutralization. (pH=9.30)

• the pH at the first equivalence point (pH=7.56)

• the pH at the 25% -neutralization point of the second neutralization. (pH=5.81)

• the pH at the 50% -neutralization point of the second neutralization. (pH=5.33)

• the pH at the 75% -neutralization point of the second neutralization. (pH=4.85)

• the pH at the second equivalence point.(pH=3.35)

Be sure to plot all nine points. (Find the HCl volumes of the pH's in mL. Also plot points on graph.)

The atmosphere slowly oxidizes hydrocarbons in a number of steps that eventually convert the hydrocarbon into carbon dioxide and water. The overall reactions of a number of such steps for methane gas is as follows: CH4(g)+5O2(g)+5NO(g)→CO2(g)+H2O(g)+5NO2(g)+2OH(g) Suppose that an atmospheric chemist combines 145 mL of methane at STP, 885 mL of oxygen at STP, and 55.0 mL of NO at STP in a 2.0 −L flask. The reaction is allowed to stand for several weeks at 275 K.

If the reaction reaches 92.0% of completion (92.0% of the limiting reactant is consumed), what are the partial pressures of each of the reactants in the flask at 275 K?

For the reaction shown, compute the theoretical yield of the product in grams for each of the following initial amounts of reactants.
Ti(s)+2F2(g)→TiF4(s)

a. 1.0 gTi; 1.0 gF2

b. 4.8 gTi; 3.2 gF2

c. 0.388 gTi; 0.341 gF2

Express your answer using two significant figures.

To make 10X gel electrophoresis running buffer, 30.0 g Tris base, 144.0 g glycine, and 10.0 g SDS must be dissolved into 1000 mL water. The working stock is a 1X concentration. a. What is the concentration in % w/v of each of the 3 reagents in the 10X stock? b. Describe how you would make 1 L of a 1X working stock solution. c. If 50 mL of the 1X working stock are used to run a gel, how many grams of each of the 3 reagents are in the 1X solution?

Why is charcoal sometimes used in recrystallizations? How does it function? Why should you avoid using large amounts? "Activated carbon" is used in air and water purifiers. How does it work?

1a- Discuss the vaporization of water in standard condition at 298 K in term of: - exothermicity and endothermicity - change of entropy of the system and the surrounding - spontaneity of the reaction.

1b- Explain how the temperature and the composition of the two phases (liquid and vapour) influence the spontaneity of the vaporization of water.