In: Chemistry
please answer all or explain.
11. Circle the statement that is not true for hemoglobin.
A.The R-state has a high affinity for diatomic oxygen.
B. 2,3-bisphosphoglycerate stabilizes the T-state.
C. Carbon monoxide stabilizes the R-state.
D. H+ ions stabilize the R-state.
12. Circle the statement that is not true for CO2.
A. It is a non-polar molecule that can diffuse across cell membranes.
B. It can combine with terminal amines on proteins to form carbamates.
C. It is primarily transported in the blood as HCO3.
D. It inhibits the release of O2 from hemoglobin.
13. What environmental pressure is considered responsible for keeping the sickle cell gene in the human gene pool?
14. Circle the statement that is not true for an enzyme.
A. It reduces ΔG for a reaction.
B. It stabilizes the transition state in a reaction.
C. It increases the reaction rate in both the forward and reverse directions.
D. It has a catalytic site that is a crevice or cleft in the molecule.
15. What are the two types of cofactors that interact with enzyme? (8 points)
11. D) H+ ions stabilize the R-state.
acidity stabilizes the deoxyhemoglobin or T state. This causes the T state, which has less affinity for oxygen, to be more prominent which pushes for oxygens to be released from hemoglobin.
12. D) It inhibits the release of O2 from hemoglobin.
The high carbon dioxide levels in the tissues lowers the pH, and the binding of haemoglobin to carbon dioxide causes a conformational change that facilitates the release of oxygen.
13. an external pressure ( environmental pressure) of about 75 atm and above shows adverse effects in SCD ( sicle cell disease) because of low oxygen partial pressures at higher atmospheric pressure.
14. D)It has a catalytic site that is a crevice or cleft in the molecule.
cleft or crevice is a site present in al enzymes to which a substrate mlecule binds
15. coenzymes and prosthetic groups are the two types of cofactors that interact with enzyme