Question

1. What percentage of the drug in an MDI is actually deposited in the lungs? Why is there so much variability?

2. Put the following steps of optimal MDI delivery in order.

1. Hold your breath
2. Breathe out normally
3. Wait 1 minute
4. Shake the canister
5. Hold the MDI two fingers from mouth
6. Slowly inhale as deep as you can
7. Warm the canister
8. Actuate the canister

3. What class of inhaled drugs requires that you always use a spacer or chamber?

4.How does DPI breathing technique differ from that recommended with a MDI?

Answer 1

What percentage of the drug in an MDI is actually deposited in the lungs?
Ans) only 10–20% of the emitted dose is deposited in the lung

following steps of optimal MDI delivery in order.

1. Warm the canister.
2. Shake the canister.

3. Hold the MDI to finger went from the mouth.

4. Breathe out normally. 5. Fire the canister.

6. Slowly inhale as deep as you can.

7. Hold your breath.

8. Wait one minute

What class of inhaled drugs requires that you always use a spacer or chamber?

Metered dose inhalers (MDIs), dry powder inhalers (DPIs), and nebulizers are modes of aerosol drug delivery that are used to treat respiratory disorders (eg, asthma, obstructive lung disorders, cystic fibrosis, pulmonary arterial hypertension, infectious pulmonary disease).

A spacer is an external device that is attached to an MDI to allow for better drug delivery by enhanced actuation and inhalation coordination.

How does DPI breathing technique differ from that recommended with a MDI?

DPI, inhalation must be rapid to generate sufficient flow to aerosolize the dry powder. With MDI the key is a slow, deep inspiration. Children under 5 and patients unable to generate a high air flow.