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Hydrochlorothiazide is a mild diuretic that affects distal tubule of the nephron. Specifically, it blocks the...

Hydrochlorothiazide is a mild diuretic that affects distal tubule of the nephron. Specifically, it blocks the reabsorption of NaCl in the distal tubule. Consider this mechanism of action, and answer the following questions:

How does this medication affect the amount of NaCl in the tubular fluid?

Will this make the tubular fluid more or less concentrated?

How will this affect the reabsorption of water in the collecting duct?

How will this affect the urine volume/output?

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