Question

this question is related to pharmacology you can answer in your own opinion

Most stimulus-response curves follow Michaelis-Menton kinetics. Two key parameters are Vmax and Km. What is the significance of each of these? What is meant by the “coupling efficiency factor” in relation to the stimulus response cascade?

Answer 1

Vmax and Km

Vmax and Km are two parameters which define the kinetic behavior of an enzyme . Vmax is the reaction rate when the enzyme is fully saturated by substrate ,indicating all the binding dites are being constantly reocvupied.

The maximal rate, Vmax reveals the turnover number of an enzyme. It is the number of substrate molecules converted in to product by an enzyme molecule in a unit time when the enzyme is fully saturated with substrate.

Km is the concentration of substrate which permits the enzyme to achieve half Vmax.it is value is used as aeasure of an enzyme's affinity for its substrate. The lower the Km value the higher the enzyme 's affinity for the substrate and opposite too.Km value also provides an idea of binding of the substrate to the enzyme molecules.

*** Coupling efficiency factor***

Coupling efficiency factor is usually expressed as a ratio converted into percent of the in put power. I,e available lower from one component to the power transferred to the other components.

The light from the lamp functions as a detectable change in the plants environment. As a result the plant exhibit a reaction of phototropism directional growth towards the light stimulus.

In our body also, there is lot of fight to fight reactions like this.The external stimuli are capable of producing systemic responses through out the body.