List the sequence of activities that a B cell undergoes after activation to a protein antigen....

List the sequence of activities that a B cell undergoes after activation to a protein antigen. Begin with the process o f activation of a B cell (specifically identify each step in activation), then continue until after the centrocyte has interacted with the follicular dendritic cell and follicular helper T cell and has made plasma and memory cells. These memory and effector B cells make IgA antibody.

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Expert Solution

Activation of B cell
B cell is having a antigen binding receptor in the membrane and this receptor is a membrane bound antibody.The protein antigen molecule will bind with the B cell antibody molecule.
The binding of antigen and antibody results in cell clevage or cell division with the help of differentiating cytokines.
The cell proliferation also takes place with the help of proliferating cytokines.
The centrocyte ( activated B cells) will interact with thefollicular dendritic cell and follicular helper T cells and resulting in the formation of memory B cells ( long lived) and plasma cells ( effector B cells).
Membrane B cell act as an membrane bound antibody,but plasma cells cannot act as membrane bound antibody. But it can secrte antibody in enormous amount ( more than 2000 molecules per second).
Antibody secreted by the plasma cells can be used for immune response and it contribute humoral immunity.

gladiator answered 1 year ago

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