Question

In: Advanced Math

1. This exercise is based on one in Hartman (2007). A pharmaceutical company needs to use...

1. This exercise is based on one in Hartman (2007). A pharmaceutical company needs to use a supercomputer to run simulation models as part of its research on cures for AIDS, cancer, and other diseases. The firm expects to perform thousands of simulation runs per year for the next 3 years. The firm can purchase a supercomputer for $2.5 million; the annual operating and maintenance costs are $200,000 per year, and the supercomputer can perform 15,000 runs per year. For every simulation run above 15,000 in a year, the operating costs rise $1,000 per year to cover the needed overtime. A second alternative is to outsource the simulation runs to an IT firm that offers supercomputing services on demand. They will charge the pharmaceutical company $400 per simulation run. Consider a 3-year time horizon, and assume that the number of runs per year is the same every year. The firm is not sure how many simulation runs they will need to perform each year. What is the range of total cost if the number of simulation runs varies from 10,000 to 20,000 runs per year? For what range of activity (number of simulation runs per year) is purchasing a supercomputer the lowest cost alternative?

2. Consider the supercomputer example from Exercise 1 above. The firm is not sure about some of the relevant costs. The following probability distributions reflect their beliefs about the uncertain costs: the annual operating and maintenance costs are uniformly distributed on the range [$150,000, $250,000]; the additional operating costs for simulation runs above 15,000 per year are uniformly distributed on the range [$500, $1500] (per run per year). Use the method of moments to estimate the mean and variance of the costs if the firm purchases the supercomputer and they perform 20,000 runs per year. Use Monte Carlo sampling to estimate the distribution of costs if the firm purchases the supercomputer and they perform 20,000 runs per year.

Solutions

Expert Solution

SOLUTION:

Given that data This exercise is based on one in Hartman (2007). A pharmaceutical company needs to use a supercomputer to run simulation models as part of its research on cures for AIDS, cancer, and other diseases. The firm expects to perform thousands of simulation runs per year for the next 3 years. The firm can purchase a supercomputer for $2.5 million; the annual operating and maintenance costs are $200,000 per year, and the supercomputer can perform 15,000 runs per year. For every simulation run above 15,000 in a year, the operating costs rise $1,000 per year to cover the needed overtime. A second alternative is to outsource the simulation runs to an IT firm that offers supercomputing services on demand. They will charge the pharmaceutical company $400 per simulation run

So

==>Total cost= Fixed cost + fixed O&M costs + Overtime costs

Fixed cost for 3 years= 2.5 million+0.2 million of O&M cost per year*3 years= 3.1 million USD ; this cost is upto 15000 simulations/year for next 3 years

1)   

   Thus, the range of cost is as follows:

No overtime cost till 15000 runs and 1000 USD/run of overtime cost beyond 1000 Runs

No. of Runs

System pruchase cost

fixed O&M cost for 3 years

Over time cost for 3 years

Total cost for 3 years

Cost/Runs

10000

     25,00,000

              6,00,000

0

     31,00,000

       103.33

11000

     25,00,000

              6,00,000

0

     31,00,000

          93.94

12000

     25,00,000

              6,00,000

0

     31,00,000

          86.11

13000

     25,00,000

              6,00,000

0

     31,00,000

          79.49

14000

     25,00,000

              6,00,000

0

     31,00,000

          73.81

15000

     25,00,000

              6,00,000

0

     31,00,000

          68.89

16000

     25,00,000

              6,00,000

       30,00,000

     61,00,000

       127.08

17000

     25,00,000

              6,00,000

       60,00,000

     91,00,000

       178.43

18000

     25,00,000

              6,00,000

       90,00,000

1,21,00,000

       224.07

19000

     25,00,000

              6,00,000

    1,20,00,000

1,51,00,000

       264.91

20000

     25,00,000

              6,00,000

    1,50,00,000

1,81,00,000

       301.67

               

2)    

  Assume Y to be the number of per year simulations over which outsourcing cost will be equal to the in-house cost. Then,

3*400*Y=2.5 million + 0.2 million of fixed yearly O&M cost*3 years+ 1000 USD /run of overtime cost *(Y-15000)*3 years

Thus, Y=23277 simulations/year

Hence, till 23277 simulations/year- it will be cheaper to do it in-house than outsource.

Also, between 14000-15000 simulations/year- the cost of in-house setup will be cheapest.


Related Solutions

Use SPSS for this Application Exercise: A pharmaceutical company tested three formulations of a pain relief...
Use SPSS for this Application Exercise: A pharmaceutical company tested three formulations of a pain relief medicine for migraine headache sufferers. Volunteers were selected and randomly assigned to one of the three drug formulations. The volunteers were instructed to take the drug during their next migraine headache episode and to report their pain on a scale of 1 to 10 (10 being most pain). The data are below. What can be concluded with ? = 0.05? formulation A formulation B...
Roberta is president of a pharmaceutical company which is based in the U.S., but has a...
Roberta is president of a pharmaceutical company which is based in the U.S., but has a substantial amount of sales in other countries. Roberta's company manufactures drugs prescribed to those infected with HIV and other illnesses. She is informed by missionary workers that millions of people in Africa have HIV and many have died. She receives a request to provide medication to certain locations in Africa free of charge. In addition, Roberta has been asked by a group in the...
Question 3 (Total 6 marks) Biogen Pharmaceutical Ltd is a large pharmaceutical company based in Australia....
Question 3 (Total 6 marks) Biogen Pharmaceutical Ltd is a large pharmaceutical company based in Australia. During the year ending 30 June 2020, Biogen Pharmaceutical Ltd purchased two electronic databases containing scientific data related to respiratory drugs. Database A was acquired for $1,000,000 and contains data that is copyright protected. Database B was acquired for $800,000 and contains data that is not copyright protected. Required (a) Explain whether Database A and Database B satisfy: (i) The definition of an intangible...
Oman Pharmaceutical Industries Co. (OPP) is one of the fastest growing pharmaceutical company in GCC. It...
Oman Pharmaceutical Industries Co. (OPP) is one of the fastest growing pharmaceutical company in GCC. It manufactures four joint products Azithromycin, Clarithromycin, Levofloxacin and Moxifloxacin from a chemical process. After further processing, the company sells Azithromycin, Clarithromycin, Levofloxacin and Moxifloxacin at a price of RO 20, RO 24, RO 16 and RO 12 and estimates a profit of 17.5%, 12.5%, 12.5% and 15% respectively. The costs incurred till the split- off point are RO 39,000. The output achieved at the...
1.A pharmaceutical company is testing their new nicotine patch. They randomly assign 100 volunteers to use...
1.A pharmaceutical company is testing their new nicotine patch. They randomly assign 100 volunteers to use the patch and finding that 37 had quit smoking after 8 weeks. Compute the 96% confidence interval. You DO need to check CLT here. 2.For # 32 .In the United States, the population mean height for 3-year-old boys is 38 inches. Suppose a random sample of 30 non-U.S. 3-year-old boys showed a sample mean of 37.2 inches with a standard deviation of 3 inches....
AstraZeneca is global pharmaceutical company based in UK. Is AstraZeneca a growth company? Does AstraZeneca have...
AstraZeneca is global pharmaceutical company based in UK. Is AstraZeneca a growth company? Does AstraZeneca have a growth stock? How does AstraZeneca deal with a business cycle?
THIS QUESTION IS BASED UPON JAVA PROGRAMMING. Exercise 1 In this exercise, you will add a...
THIS QUESTION IS BASED UPON JAVA PROGRAMMING. Exercise 1 In this exercise, you will add a method swapNodes to SinglyLinkedList class. This method should swap two nodes node1 and node2 (and not just their contents) given references only to node1 and node2. The new method should check if node1 and node2 are the same nodes, etc. Write the main method to test the swapNodes method. Hint: You may need to traverse the list. Exercise 2 In this exercise, you will...
You are a manager at a pharmaceutical company, and one of your scientists has developed a...
You are a manager at a pharmaceutical company, and one of your scientists has developed a new statin that has no side effects. The initial cost to launch the drug will be $1,000,000. The revenue is projected to be produced according to one of two timelines, based on marketing. The first timeline has revenues of $100,000, $300,000, and $900,000 in years 1, 2, and 3, respectively. The second timeline has revenues of $900,000, $300,000, and $100,000 in years 1, 2,...
One pharmaceutical company claims their flu vaccine reduces the risk of illness by 40%. One political...
One pharmaceutical company claims their flu vaccine reduces the risk of illness by 40%. One political pundit believes that the real percentage is less. He does a study and the conclusion of the statistical test is to reject the null hypnosis. According to the CDC recent studies show that flu vaccinations reduce the risk of illness by between 40% and 60%. Given this information answer the following questions. (a) State the null hypothesis as a mathematical statement. (b) State the...
4. A pharmaceutical company plans to use a liquid-liquid extraction to purify a drug that is...
4. A pharmaceutical company plans to use a liquid-liquid extraction to purify a drug that is a weak monoprotic base. The chemical has a pKb = 9.52 at 25oC. The KD for the neutral form of this chemical is 210 when using water and chloroform at 25oC. a. What fraction of this drug will be extracted from a 15.0 mL aqueous sample into 10.0 mL of chloroform at pH = 9.00 and 25oC? b. What fraction of this drug will...
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT