A male patient weighing 68 kg is placed on heparin therapy for the prevention of deep vein thrombosis after surgery. DO NOT include units with your responses, these were provided.

(a) How many milliliters (to nearest tenth) of a heparin injection containing 5000 units/mL should be administered for a loading dose of 80 units/kg?
(b) What should be the infusion rate, in mL/hr (rounded to nearest tenth), using a solution that contains heparin 25,000 units/500 mL, to administer 18 units/kg/hr?
(c) Six hours after heparin therapy is initiated, the patient's aPTT is found to be 75 seconds. Adjust the infusion rate, in mL/hr (rounded to a whole number), according to the adult weight based heparin protocol (see Fig. 10.1, text page 168).

Expert Solution

a) How many milliliters (to nearest tenth) of a heparin injection containing 5000 units/mL should be administered for a loading dose of 80 units/kg?

Weight of the patient = 68kg

Available dose = 5000IU/ml

Ordered dose = 80units/kg

= 80units 68kg

= 5440units

ml/dose= Ordered dose / available dose per ml

= 5440 / 5000

= 1.088ml

= 1.1ml

(b) What should be the infusion rate, in mL/hr (rounded to nearest tenth), using a solution that contains heparin 25,000 units/500 mL, to administer 18 units/kg/hr?

Weight of the patient = 68kg

Available dose = 25000units/500ml

Therefore, 1ml = 25000/500

1ml = 50units

Ordered dose = 18units/kg/hr

= 1868

= 1224units/hr

ml/hr = Ordered dose/ Available dose in 1ml

= 1224units/ 50units

= 24.48ml/hr

= 24.5ml/hr

(c) Six hours after heparin therapy is initiated, the patient's aPTT is found to be 75 seconds. Adjust the infusion rate, in mL/hr (rounded to a whole number), according to the adult weight based heparin protocol

According to the protocol, if aPTT after six hours of heparin therapy is 70-120seconds, then there is no need to change the dose. Continue with the same infusion for the next six hours and repeat aPTT there after.

Nightingale answered 2 years ago

The anticoagulant heparin is used for preventing blood clots of patients after surgery, and for the treat- ment and prevention of deep vein thrombosis.

"Sex","Age","Weight","Dose","Heparin" "Male",51,146.94,"High",-1.654 "Male",48,115.08,"High",1.489 "Male",65,83.54,"Low",1.757 "Male",44,94.94,"High",1.324 "Male",43,122.46,"High",-2.86 "Male",54,135.86,"Low",-3.55 "Male",44,116.91,"Low",-1.682 "Male",36,126.98,"High",-0.603 "Male",43,95.9,"High",1.58 "Male",55,127.79,"Low",-1.428 "Male",37,98.58,"High",1.345 "Male",53,121.99,"High",-0.58 "Male",46,74.96,"High",4.47 "Male",53,99.17,"High",0.674 "Male",46,78.35,"High",4.488 "Male",40,122.13,"High",-1.134 "Male",28,81.31,"High",2.617 "Male",37,134.13,"High",-1.895 "Male",39,84.23,"High",2.799 "Male",49,101.35,"Low",0.571 "Male",36,109.39,"Low",-0.41 "Male",48,90.31,"Low",1.116 "Male",40,108.31,"Low",-1.311 "Male",44,117.91,"High",-0.263 "Male",43,97.58,"Low",-1.211 "Male",42,116.8,"Low",-0.174 "Male",37,139.32,"Low",-3.19 "Male",41,108.24,"High",2.052 "Male",35,96.67,"High",0.653 "Male",37,162.38,"Low",-7.441 "Male",45,93.29,"High",1.58 "Male",38,100.41,"High",1.413 "Male",39,81.97,"Low",1.037 "Male",42,89.27,"Low",3.623 "Male",43,89.66,"High",1.49 "Male",40,158.19,"High",-4.324 "Male",37,118.59,"Low",-2.981 "Female",25,77.05,"High",3.94 "Female",38,120.97,"Low",0.666 "Female",42,83.59,"High",5.294 "Female",21,122.16,"Low",1.985 "Female",45,104.93,"High",3.339 "Female",42,70.12,"Low",3.86 "Female",44,92.88,"High",3.422 "Female",46,85.94,"Low",3.293 "Female",43,82.45,"High",4.074 "Female",45,95.56,"High",3.378 "Female",44,86.14,"Low",1.923 "Female",42,82.81,"High",3.494 "Female",51,142.11,"Low",-0.577 "Female",32,87.04,"Low",3.48 "Female",31,82.02,"High",4.136 "Female",59,100.19,"High",4.345 "Female",43,69.19,"High",7.576 "Female",34,106.71,"High",2.712 "Female",42,73.74,"High",3.608 "Female",57,115.93,"High",1.48 "Female",58,59.41,"High",6.555 "Female",43,96.76,"Low",2.277 "Female",39,106.94,"Low",2.377 "Female",43,100.03,"Low",2.377 "Female",35,113.35,"Low",0.049 "Female",39,84.42,"High",5.673 "Female",48,69.54,"Low",5.119 "Female",46,86.53,"High",3.85 "Female",40,123.97,"High",2.478 "Female",46,84.2,"High",2.878 "Female",41,91.71,"High",2.95 "Female",28,84.41,"High",3.88 "Female",45,107.26,"High",2.764 "Female",45,100.1,"High",2.806 "Female",49,80.98,"Low",4.686 "Female",51,94.32,"Low",1.479 "Female",43,91.91,"Low",1.756 "Female",37,91.22,"Low",1.803 "Female",49,68.84,"High",6.17 "Female",53,107.24,"Low",2.13 "Female",38,73.65,"High",4.419 "Female",43,71.33,"Low",3.795...

Question

A male patient weighing 68 kg is placed on heparin therapy for the prevention of deep vein thrombosis after surgery. DO NOT include units with your responses, these were provided.

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The anticoagulant heparin is used for preventing blood clots of patients after surgery, and for the treat- ment and prevention of deep vein thrombosis.