A number of drugs with different properties are shown below. Which of these drugs are most...

A number of drugs with different properties are shown below. Which of these drugs are most likely to cross the blood-brain barrier? (select all that apply)

- High molecular weight drug

- Low molecular weight drug

- Water-soluble drug

- Fat-soluble drug

- Nonpolar drug

- Small drug

- Polar drug

Expert Solution

The blood brain barrier is a highly selective semipermeable border of endothelial cells that prevents solutes in the circulating blood from non selectively crossing into the extracellular fluid of the central nervous system where neurons reside.

All except high molecule and water soluble drugs can cross the Blood brain barrier.

The blood brain barrier is automatically and functionally distinct from the blood cerebrospinal fluid barrier at the choroid plexus. Certain small molecular drug (low molecule drugs) may cross the blood brain barrier via lipid mediated free diffusion, providing the drug ha s a molecular weight <400 da and form <8 hydrogen bonds.

Fat soluble substances dissolve in the cell membrane and cross the barrier by passive diffusion.

Water soluble substances have difficulty in getting through.

Nonpolar agents are lipophilic,they can cross the blood brain barrier by diffusing through the lipid membranes of the endothelial cells.

Polar drugs charged structure makes them aversive to the lipids in the membrane of the endothelial cells .Its difficult feo them to diffusion through the tight junctions.

High molecule drugs and water soluble drugs can not cross the blood brain barrier.

Nightingale answered 1 year ago

There are a number of empirical "laws" which relate different bulk continuum properties of materials. Describe...

There are a number of empirical "laws" which relate different bulk continuum properties of materials. Describe these laws. Can you provide an explanation for each of these laws simply on the basis of the material as a "black box" ?

Which pair of elements from different groups resemble each other the most in their chemical properties?...

Which pair of elements from different groups resemble each other the most in their chemical properties? Be and B Al and Si O Li and Mg Be and C

four risk differences and their 95% confidence intervals are shown below. which of these is most...

four risk differences and their 95% confidence intervals are shown below. which of these is most precise? A.) -0.15 (-0.25, 0.05) B.) -0.15 (-0.45, 0.15) C.) -0.15 (-0.17, -0.13) D.) -0.15 (-0.33, 0.03)

Some of the properties of strong and weak acids are different. All statements below are properties...

Some of the properties of strong and weak acids are different. All statements below are properties of weak acids except for: a. Weak acids dissociate only slightly in water b. Weak acids dissociate completely if the pH is raised c. Weak acids have a pKa d. Weak acids can serve as buffers E. Weak acids dissociate completely at an pH

which of the following properties is associated with the value of the mlquantum number? a. the...

which of the following properties is associated with the value of the mlquantum number? a. the orientation of the orbital in space b. the size of the orbital c. the shape of an orbital d the number of full orbitals

5. The skin possesses a number of amazing protective properties, and one of the most notable...

5. The skin possesses a number of amazing protective properties, and one of the most notable is skin coloration as a protection against U.V. irradiation. Briefly, describe the anatomical, biochemical and physical means by which the skin adapts to U.V. radiation. How does light (U.V.) potentially disrupt cellular function and how is melanin poised to protect against damage. Describe four features of melanin as it relates to interpersonal differences between individuals, and what impact does this have on rates of...

Selected accounts of Piotroski Properties, a real estate management firm, are shown below as of January...

Selected accounts of Piotroski Properties, a real estate management firm, are shown below as of January 31, before any accounts have been adjusted. Debits Credits Prepaid Insurance $19,980 Supplies 5,790 Office Equipment 17,856 Unearned Rent Revenue $15,750 Salaries Expense 9,300 Rent Revenue 45,000 Piotroski Properties prepares monthly financial statements. Using the following information, adjust the accounts as necessary on January 31 using the financial statements effect template. (a) Prepaid insurance represents a three-year premium paid on January 1. (b) Supplies...

Number of replies: 0 1- Describe some of the most common used drugs among teenagers and...

Number of replies: 0 1- Describe some of the most common used drugs among teenagers and their possible dangerous effects. 2- What are risk factors for Child abuse and how can they be prevented? 3- Why is the elderly population more at risk for substance abuse? How can the nurse prevent or identify patients at risk? 4- What is trauma/shaken baby syndrome ? 5- What are the different types of elderly abuse, provide example.

The most profitable prescription drugs are those which are still on patent so that the producer...

The most profitable prescription drugs are those which are still on patent so that the producer essentially has a monopoly on the drug while the patent lasts. There are many drugs for which the patent has expired and therefore there are generic drugs available (Advil and generic ibuprofen, Tylenol and generic acetaminophen, etc.). What can you say about the price of these generic drugs and the cost of producing these generic drugs? Please give an explanation.

Which statement below is most correct?

Which statement below is most correct? a) The economic theory of the firm focuses upon explaining firms' decision making by assuming firms are primarily motivated by attempting to maximize their contribution to general public's social welfare. b) The theory of the firm holds that the primary goal of a firm is to maximize the discounted present value of the positive difference between the firm's total revenue and the firm's total cost or to minimize the present value of the negative difference between the firm's total revenue...

Question