Question

1. what is the shape of the concentration-signal curve when the reagent is saturated with excess antigen.

2.what is the graphical representation of observed values of a control material over time in the context of the upper and lower control limit.

3. in hyperlipidemic and hyperproteinemic samples, excess lipids and protein displaces plasma electrolytes which leads to a falsely decreased measurement of ionic activity in millimoles per litter of plasma. (true or false)

4. is the ability of a method to detect only the analyte it is designed to determine.

5.biosecurity is-

6. The number of control values enough to set up a Levey-Jennings control chart

7. accuracy is-

8.precision is-

9. Rationale of Order of Draw?

10. The proper collection of samples for ionized calcium measurements requires great care because loss of HCO3 will increased pH which may affect concentration of iCa. (True or False)

11. a multi Westgard rulling wherein one control observation exceeding the mean +/-3s, allow high sensitivity to random error.

12. Is a type of cabinet used to contain and expel noxious and hazardous fumes from chemical reagents.

13. is the ability of a method to detect small quantities of an analyte

14. the ISEs are the most routinely used method in clinical laboratories in analyzing serum electrolytes. (True or false)

15.proper collection and handling of samples for potassium analysis is extremely important because there are many causes of artifactual hyperkalemia one of which is if patients excessively clench their fist during blood sample collection. (true or false)

Answer 1

SOLUTION for 3rd question: It is true that  in hyperlipidemic and hyperproteinemic samples, excess lipids and protein displaces plasma electrolytes which leads to a falsely decreased measurement of ionic activity in millimoles per litter of plasma.

SOLUTION for 6TH question: 1_2s refers to the control rule that is commonly used with the Levey - jennings control chart when the control limits are set as the mean +/_2s, This rule is used to reject a run when single control measurement exceeds a 2s control limit.

1_3s corresponds to a levey jennings chart having control limits set as the mean +/_3s. An analytucal run is rejected when a single control measurement exceeds 3s control limit.

SOLUTION for 10th question: calcium concentration values change inversely to pH that means ionized calcium binds negatively charged sites that competes with the hydrogen ions. this binding is pH dependent and alters the level of ionized calcium levels. so it is true that  proper collection of samples for ionized calcium measurements requires great care.

SOLUTION for 14th question: it is true that Ion selective electrodes (IES)  are the most routinely used method in clinical laboratories in analyzing serum electrolytes.

SOLUTION for 15th question: fist clenching is not recommended as it causes local release of potassium from the forearm muscle and increase blood flow. it is true that artifactual hyperkalemia one of which is if patients excessively clench their fist during blood sample collection.so it is important for collection and handling of samples for potassium  analysis.