Question

List as many ingredients as you can that are suitable for dissolving hydrophobic organic drugs for use in intra-muscular injections.

Answer 1

Hydrophobic drugs have poor solubility in water. This drugs are not always soluble in different organic solvents.

The dissolution of solute in solvent(solubility ) produces a homogeneous system which helps to produce a desirable pharmacological action of that particular medicine. Therefore low solubility is a major problem. Various techniques and technologies are used for increasing the solubility of hydrophobic drugs. That are listed below:

1. pH modifiers

2. Hydrophilic surfactants

3. Cosolvents in conjunction with surfactants and pH modifiers

E.g : Glycerin, PEG 300, PEG 400, Polysorbate 80, Propylene glycol

4. Carriers using solid dispersion technology

E.g: HPMC, PVP, PEG

5. Polymeric micelles

E.g: Genexol-PM, Estrasob

6. Inclusion complexation

E.g: Cyclodextrins

7. Solid lipid nanoparticles (SLN)

E.g: Monostearin, stearic acid, oleic acid, triluarin

8. Liposomes and proliposomes

E.g: Mikasome, Ventas

9. Microemulsiions and self emulsifying drug delivery systems :

E.g: Liple, vitalipid, diazemuls