List as many ingredients as you can that are suitable for dissolving hydrophobic organic drugs for...

List as many ingredients as you can that are suitable for dissolving hydrophobic organic drugs for use in intra-muscular injections.

Expert Solution

Hydrophobic drugs have poor solubility in water. This drugs are not always soluble in different organic solvents.

The dissolution of solute in solvent(solubility ) produces a homogeneous system which helps to produce a desirable pharmacological action of that particular medicine. Therefore low solubility is a major problem. Various techniques and technologies are used for increasing the solubility of hydrophobic drugs. That are listed below:

1. pH modifiers

2. Hydrophilic surfactants

3. Cosolvents in conjunction with surfactants and pH modifiers

E.g : Glycerin, PEG 300, PEG 400, Polysorbate 80, Propylene glycol

4. Carriers using solid dispersion technology

E.g: HPMC, PVP, PEG

5. Polymeric micelles

E.g: Genexol-PM, Estrasob

6. Inclusion complexation

E.g: Cyclodextrins

7. Solid lipid nanoparticles (SLN)

E.g: Monostearin, stearic acid, oleic acid, triluarin

8. Liposomes and proliposomes

E.g: Mikasome, Ventas

9. Microemulsiions and self emulsifying drug delivery systems :

E.g: Liple, vitalipid, diazemuls

Nightingale answered 1 year ago

A reduction reaction can be carried on many organic compounds. It is the reverse of an...

A reduction reaction can be carried on many organic compounds. It is the reverse of an oxidation reaction. Which of the following statements is true? A reduction reaction can be carried on many organic compounds. It is the reverse of an oxidation reaction. Which of the following statements is true? Reduction reactions are characterized by the increase in the number of carbon-oxygen bonds. Reduction reactions are characterized by the decrease in the number of carbon-oxygen bonds. Alcohols are reduced to...

list as many of the parts of fundamental theorem of linear algebra as you can. An...

list as many of the parts of fundamental theorem of linear algebra as you can. An nxn matrix A is invertible if and only if ....

List procedures or treatments that require a consent form. As many as you can.

can you think of alternatives to the criminalization of drugs?

How can you identify organic molecules?

How can you identify organic molecules? Give details explaination.

List as many differences between internal and external auditors as you can find.

List as many features as you can that facilitate the mobility of the glenohumeral joint. Think...

List as many features as you can that facilitate the mobility of the glenohumeral joint. Think about the shape of the capsule, shape of the joint surfaces, ligaments, structures around the joint, accessory joints, and bones that contribute to full range of movement around the shoulder. Consider how these affect the mobility of the shoulder joint and shoulder complex, and how they may be a tradeoff for loss of stability. Factors increasing mobility of the joint: - Bones: - Capsule:...

Many organic molecules act as acids and bases and can exist in an acid or base...

Many organic molecules act as acids and bases and can exist in an acid or base form. For each molecule, match the following acid or base with its' conjugate base or acid 1. CH3NH2 2. CH3CH2O- 3. CH3CH2N(CH3)3+ 4. CH3CH2OCH3 5. (CH3)3NH+ a.CH3NH3+ b. (CH3)2NH2+ c. CH3CH2O- d. CH3CH2OH e.(CH3)3N f. CH3CH2OOH g. none of these

Instructions: 1) Below you will see the Nutrition Facts Panel and the Ingredients list for two...

Instructions: 1) Below you will see the Nutrition Facts Panel and the Ingredients list for two very similar products. Then you will see the ingredients list for another unrelated product. Read the information on the NFP and Ingredients list and answer the questions on the question form to turn in. Then, find an alternative to these products that is a more whole food and talk about it in discussions. See the discussion forum for the specific details/requirements. LC Thai Chicken...

The following is a list of drugs. For this assignment, use any resources available to you...

The following is a list of drugs. For this assignment, use any resources available to you to find the structures and the pKa of these drugs. Identify the functional groups on each drug that will readily ionize under the appropriate pH conditions. Finally, determine the degree of ionization of the drug at physiological pH (7.4). MDMA Amphetamine Butalbital Hydrocodone Carisoprodol I understand how to find the functional groups. I need help understanding how to calculate the degree of ionization. With...

Question