List as many ingredients as you can that are suitable for dissolving hydrophobic organic drugs for...

List as many ingredients as you can that are suitable for dissolving hydrophobic organic drugs for use in intra-muscular injections.

Expert Solution

Hydrophobic drugs have poor solubility in water. This drugs are not always soluble in different organic solvents.

The dissolution of solute in solvent(solubility ) produces a homogeneous system which helps to produce a desirable pharmacological action of that particular medicine. Therefore low solubility is a major problem. Various techniques and technologies are used for increasing the solubility of hydrophobic drugs. That are listed below:

1. pH modifiers

2. Hydrophilic surfactants

3. Cosolvents in conjunction with surfactants and pH modifiers

E.g : Glycerin, PEG 300, PEG 400, Polysorbate 80, Propylene glycol

4. Carriers using solid dispersion technology

E.g: HPMC, PVP, PEG

5. Polymeric micelles

E.g: Genexol-PM, Estrasob

6. Inclusion complexation

E.g: Cyclodextrins

7. Solid lipid nanoparticles (SLN)

E.g: Monostearin, stearic acid, oleic acid, triluarin

8. Liposomes and proliposomes

E.g: Mikasome, Ventas

9. Microemulsiions and self emulsifying drug delivery systems :

E.g: Liple, vitalipid, diazemuls

Nightingale answered 2 years ago

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