Question

1. Which of the following compounds will inhibit RNA synthesis?

A. Adenosine

B. 2' dexoyadenosine

C. 2', 3' deoxyadenosine

D. 3' deoxyadenosine

2. Which of the following is true about eukaryotic promoters?

A. They are not, themselves, transcribed

B. They are found at great distance(thousand of base pairs) from the transcription start site

C. They can trans-acting factors to the gene

D. When the promoter DNA is acetylated, transcription is activate

3. Which eukaryotic RNA polymerase is most likely to be found in the nucleolus?

A. RNA pol I

B. RNA pol II

C. RNA pol III

D. Mitochondrial RNA pol

Answer 1

Answere :

Question 1 : The correct option is Option D i.e. 3' deoxyadenosine.

Explanation : Cordycepin (3-deoxyadenosine) is an adenosine analog and, when phosphorylated, is an adenylate nucleotide analog. The absence of a 3-hydroxyl group in 3-deoxyadenosine means that it cannot form a phosphodiester linkage with another nucleotide. If cordycepin is incorporated, RNA synthesis will inhibit.

Question 2 : The correct option is Option A i.e. They are not, themselves, transcribed.

Explanation : Promoter is a region of on a DNA molecule to which RNA polymerase binds and initiate transcription. It is located just near to the transcription start site and promoter sequence are not, themeselves, transcribed.

Question 3 : The correct option is Option A i.e. RNA pol I.

Explanation : RNA polymerase I is located in nucleolus and synthesizes most rRNAs. rRNAs forms a part of ribosome.

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