In: Nursing
Three patients in your ward are due to receive a single oral dose of the same drug. The first patient is getting a 60mg dose, the second patient is getting a 120mg dose, and the third patient is getting a 180mg dose.
Assuming that all else is equal in these patients and that there is no unusual pharmacokinetics going on:
Predict what will happen (increase/decrease/no change) to half-life, Cmax and Tmax with these increasing oral doses if all other factors remain constant.
Pharmacokinetics means that the study of the time course of drug absorption, distribution, metabolism, and excretion. Pharmacokinetics is the study of what the body does to the drug. But pharmacodynamics is the study of what the drug does to the body.
The duration of action of a drug is known as its half life. This is the period of time required for the concentration or amount of drug in the body to be reduced by one-half.
Here it is evident that there is no unusual pharmacokinetics going on. Hence the half life is constant, no change in the half life.
Here all the doses are administered via oral routes. Hence the Cmax and Tmax remains same.