A miscarried fetus has primary Trisomy 16 (3 separate chromosome 16's). The chromosome 16's of the...

A miscarried fetus has primary Trisomy 16 (3 separate chromosome 16's). The chromosome 16's of the fetus, mother, and father were tested for a common polymorphism involving this chromosome. Four types of polymorphisms commonly occur in the population: A, B, C, and D. The results were: fetus = ABC, mother = AB, father = CD. When and where did the mis-segregation (non-disjunction) event causing trisomy 16 in the fetus most likely occur?

Expert Solution

Four types of polymorphisms were found in chromosome 16 trisomy as A, B, C and D. Fetus had the ABC polymorphism while mother and father had AB and CD respectively. The fetus contain two pairs from mother and one pair from father. So, non disjunction of chromosomes could have occurred in the anaphase II stage of meiosis during the development of ovum.

gladiator answered 2 years ago

The most common form of Down syndrome is known as Trisomy 21, which is when chromosome...

The most common form of Down syndrome is known as Trisomy 21, which is when chromosome number 21 receives an extra copy through nondisjunction. This leads to each cell having a total of 47 chromosomes, and while people living with Down syndrome lead long, happy lives, they can experience abnormalities in their physical growth, cognitive capabilities, and are sometimes at greater risk in terms of health. Which cell checkpoint in the cell cycle would need to malfunction for nondisjunction to...

Nondisjunction of chromosome #21 in which of the following (1-7) could result in a fetus/child with...

Nondisjunction of chromosome #21 in which of the following (1-7) could result in a fetus/child with trisomy 21 (47,XX+21) or (47,XY+21)? To indicate your choices, type an “R” at the end of each RIGHT choice, and a “W” at the end of each WRONG choice. I. Anaphase 1 in spermatogenesis II. Anaphase 2 in spermatogenesis III. Anaphase 1 in oogenesis IV. Anaphase 2 in oogenesis V. The first anaphase of a normal zygote. VI. The anaphase in one of the...

Question 16 Question 16) for each of the following separate cases, identify if the case is...

Question 16 Question 16) for each of the following separate cases, identify if the case is error or change in accounting estimate and identify the correct accounting treatment. A) In 2019, after the entity’s 2018 financial statements were approved for issue, the entity discovered that, as a result of a computational error, depreciation expense for 2018 was understated by AED 1,000. B) the CFO in Company WXY had decided to change the recognition method of investment properties from cost model...

16. Is the relationship between frequency of recombination and the distance on a chromosome between two genes...

16. Is the relationship between frequency of recombination and the distance on a chromosome between two genes always linear? Why? 17. If a proliferating cell is exposed to UV radiation causing DNA damage, at what checkpoint would the cell cycle be halted? What is the mechanism behind this control? 18. What do we mean by proofreading activity of a DNA polymerase? 19. What is a tumor suppressor gene? Explain and describe the role of Rb as an example. 20. What is an oncogene?...

6. During mitosis cells use changes in the chromosome apparatus to accurately separate their chromatid pairs...

6. During mitosis cells use changes in the chromosome apparatus to accurately separate their chromatid pairs between two cells. A. Please explain (and considering making a diagram) of how the spindle microtubules change across the process of mitosis. Please explain how chromosome attached microtubules change across mitosis and add those to your drawing. B. Please explain where and how changes in polymerization of microtubules drive these changes and how motor proteins function in this process. C. Please EXPLAIN HOW cells...

A family has four children, of age 3, 6, and 16 and 16 . Let’s assume...

A family has four children, of age 3, 6, and 16 and 16 . Let’s assume that the probability of giving birth to a boy is the same as the probability of giving birth to a girl. Determine the following probabilities: (a) that all 4 children are girls (b) that at least two of the children are boys (c) that the oldest child is a girl (d) that only three children are of the same gender (e) Given that you...

3. Describe the difference between a homologous chromosome and a sister chromatid

3. Use Matlab to find the partial fraction expansion of the functions below. a) F(s)=16(s+2)/((s+4)(s2+6s+9)) show...

3. Use Matlab to find the partial fraction expansion of the functions below. a) F(s)=16(s+2)/((s+4)(s2+6s+9)) show your Matlab commands and answers in the space below b) F(s)=(s2+2s+2)/((s+1)2(s+4)2) show your Matlab commands and answers in the space below

Consider the casual CT systems with transfer functions: H1(s)= (s+1)/(s+2)(s^2+s+16) H2(s)= s/(s+10)(s+1) H3(s)= 1/(s-1)(s+1) H4(s)= s/(s+1)(s^2+s+16)...

Consider the casual CT systems with transfer functions: H1(s)= (s+1)/(s+2)(s^2+s+16) H2(s)= s/(s+10)(s+1) H3(s)= 1/(s-1)(s+1) H4(s)= s/(s+1)(s^2+s+16) 1) Write magnitude and phase expression for their Bode Plots and Sketch their asymptotes. Verify Using Matlab. 2) Compute their steady-state response to cos(5t) u(t) + 3u(t) + cos(10t) e^-t u(t). ***Please show slope computations and conversions for the graphs. This is where I am unable to move forward.

Human fragile sites are associated with _____. chromosome breakage replication late in S phase stalling of...

Human fragile sites are associated with _____. chromosome breakage replication late in S phase stalling of DNA replication enzymes genetic disorders in certain instances All of the above

Question