why were we able to do calculations with Hardy-Weinberg by determining the PV92 genotypes ? what...

why were we able to do calculations with Hardy-Weinberg by determining the PV92 genotypes ? what about these genotypes was useful?

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Expert Solution

Hardy-Weinberg principle states that allele Frequencies of a population remain constant generation after generation if the population is large and there is no external influences like genetic drift, natural selection, migration ,immigration etc.

There are 7 assumptions of Hardy-Weinberg equilibrium ,

Organism is diploid.

Random mating.

Population is large.

Allele Frequencies are equal in the sexes.

Sexually reproducing organisms.

Non overlapping generation.

No migration, natural selection or sexual selection.

A population must obey this 7 assumptions if it is in Hardy-Weinberg equilibrium.

PV92 is an Alu sequence on chromosome 16. It is a transposeable element. PV92 is a human specific dimorphic Alu insertion. This alu elements used for DNA identification, inheritance pattern of genetic disorders, genetic mapping.

PV 92 genetic system has two alleles + and - . + indicating presence and - indicating absence. So there will be 3 genotypes : + +, + - and - -

Two form of this genotype is useful to calculate with Hardy-Weinberg equilibrium.

gladiator answered 1 year ago

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