Which statements regarding shape and charge complementarity are true? 1. Charge complementarity occurs when specific noncovalent...

Which statements regarding shape and charge complementarity are true?

1. Charge complementarity occurs when specific noncovalent binding interactions occur between two contacting surfaces.

2. The "charge" interactions can be charge-charge, H-bonding, or van der Waals interactions.

3. Shape complementarity refers to the intimate contact made between an antibody and its target antigen.

4. Shape and charge complementarity explain exclusively the interactions between an antibody and its target antigen.

a) Only statements 1, 2, and 3 are true.

b)Only statements 2, 3, and 4 are true.

c) Only statements 1, 2, and 4 are true.

d) All of the listed statements are true.

Expert Solution

1. Charge complementarity occurs when specific noncovalent binding interactions occur between two contacting surfaces. The electrostatic interactions during ligand-receptor binding leading to optimized interactions is called charge complementarity. Correct

2. The "charge" interactions can be charge-charge, H-bonding, or van der Waals interactions. Charge complementarity may include ionic interactions (among charged residues), H-bonding (among polar residues) and van-der Waals interactions (hydrophobic interaction, among non-polar residues) among the residues of a receptor and its ligand. Correct

3. Shape complementarity refers to the intimate contact made between an antibody and its target antigen. Ab-Ag binding is facilitated by shape complementarity (fitting cognate structural domains between Ab and Ag). Correct

4. Shape and charge complementarity explain “exclusively” the interactions between an antibody and its target antigen. Incorrect. Shape complementarity explains interaction between any receptor and its cognate ligand , like a hormone and its receptor.

Correct option: A. Only statements 1, 2 and 3.

queen_honey_blossom answered 2 years ago

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