De novo purine synthesis , Are nucleoside mono-, di-, or triphosphates synthesized at the end of...

De novo purine synthesis ,

Are nucleoside mono-, di-, or triphosphates synthesized at the end of this pathway?

Expert Solution

gladiator answered 2 years ago

For every pyrimidine mononucleotide synthesized de novo, 5 ATPs are consumed. For every purine nucleotide synthesized...

For every pyrimidine mononucleotide synthesized de novo, 5 ATPs are consumed. For every purine nucleotide synthesized de novo, 9 ATPs are consumed. Because of this high cost, it is essential to tightly control nucleotide synthesis to closely match the needs of the cell at any given time. When the energy charge of a cell is low, cells will not replicate DNA. There is no need for deoxyribonucleotides (dNTPs) so their synthesis is turned off. Conversely, when the energy charge is...

What is the first complete nucleotide made by the purine de novo pathway?

Why is de novo pyrimidine nucleotide synthesis regulated at the aspartate transcarbamoylase step in bacteria and...

Why is de novo pyrimidine nucleotide synthesis regulated at the aspartate transcarbamoylase step in bacteria and at the carbamoyl phosphate synthetase step in eukaryotes? B) Why isn’t the formation of 5-phosphoribosyl-1-pyrophosphate (PRPP) the regulated step in the de novo synthesis of purine nucleotides?

If de novo fatty acid synthesis is active would you expect malic enzyme to be active...

If de novo fatty acid synthesis is active would you expect malic enzyme to be active or not? Please explain.

How is the electron transport chain tied to the synthesis of nucleoside triphosphates?

how could proton nmr be used to quickly differentiate between a mono versus a di-nitration product

Draw a color-coded diagram (to indicate the origin of each atom) for the de novo biosynthetic...

Draw a color-coded diagram (to indicate the origin of each atom) for the de novo biosynthetic pathway of purine nucleotides AMP and GMP. You must provide structures and names of all the intermediates, cofactors involved, names of enzymes, and other necessary information for full credit

What is your best estimate of the rate of de novo somatic mutations? On what studies...

What is your best estimate of the rate of de novo somatic mutations? On what studies do you base your estimate? Explain the method(s) used in those studies and the assumptions on which the numbers are based.

How is the reciprocal use of nucleotides useful in purine synthesis? Which vitamin supplement is taken...

How is the reciprocal use of nucleotides useful in purine synthesis? Which vitamin supplement is taken during the first trimester of pregnancy to prevent the birth defect known as spina bifida? How is a chloroplast similar to a mitochondria in regard to energy production? Why are reactions of the Calvin cycle called the “dark reactions”?

Purines synthesis begins with a purine skeleton that will be attached to ribose 5-phosphate once it's...

Purines synthesis begins with a purine skeleton that will be attached to ribose 5-phosphate once it's complete. results in the production of deoxyribonucleotides first. is completed without folic acid. begins with ribose 5-phosphate.

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