Question
In: Biology
A 60 year old male (height 177.8 cm wt, 108.8 kg SCr = 1.5mg/dL) is admitted...
A 60 year old male (height 177.8 cm wt, 108.8 kg SCr = 1.5mg/dL) is admitted from the emergency department with cellulitis resulting in left facial swelling. Culture results show methicillin-resistant Staphylococcus aureus and the patient is now receiving vancomycin monotherapy. Using the Rodvoid equation, what does is most likely to result in a AUC of approximately 500?
A. 1000mg IV every 12 hours
B. 1500mg IV every 12 hours
C. 1000mg IV every 8 hours
D. 2000mg IV every 12 hours
Solutions
Expert Solution
Answer: The most likely result of AUC of approximately 500 for vancomycin monotherapy is D. 2000mg IV every 12 hours.
Explanation:
Cellulitis is a common bacterial skin infection caused mostly by bacteria such as Streptococcus and Staphylococcus. It is painful skin infection having swollen area, crack on skin, redness and feels softer to touch. Cellulitis mostly affects the skin of lower legs, face and anywhere on a body. Currently, methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of cellulitis. Vancomycin is a glycopeptide antibiotic. It is mostly used for treating methicillin-resistant Staphylococcus aureus infections.
The area under curve (AUC) is calculated for the exposure of a drug concentration in plasma after for a certain time. It is expressed as mg*h/L. AUC depends on administration of a drug dose and also elimination of a drug.
For a person of 65 years with height of 177.8 cm and weight of 108.8 kg having a serum creatinine of 1.5mg/dl, the AUC of approximately 500 for vancomycin produces 2000 mg IV every 12 hours.
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