In: Biology
Phosphofructokinase-1
what are some ways Phosphofructokinase-1 is like hemoglobin?
why are these similarities important?
what are the functions of all of the allosteric regulators, how do they regulate the activity of Phosphofructokinase-1?
in what way does ATP inhibit Phosphofructokinase?
Phosphofructokinase-1 is like hemoglobin?
What are the functions of all of the allosteric regulators, how do they regulate the activity of Phosphofructokinase-1?
in what way does ATP inhibit Phosphofructokinase?
If present in normal conditions it facilitates the activity of phosphofructokinase-1. But if present in excess, so it starts inhibiting phosphofructokinase-1 by a feedback negative mechanism. It is an obvious fact because PFK-1 works in the process of Glycolysis to make ATP, but if ATP is in excess we need to stop the process and this step is catalyzed by PFK-1 is committed-step, so regulation needs to occur on this step.