Describe how cdc2 kinase activity is controlled by interacting with Cyclin, cdc25, CAK and by phosprylation/dephosphorylation.

Expert Solution

Answer: The mechanism of phosphorylation/dephosphorylation of cdc2 kinase (CDK) is given below in handwritten with typed explanation further:

CDK activity is first regulated by cyclin which changes cyclically. M-cyclin assembly with cdc 2 subunit of CDK leads to M-CDK complex formation which is kept inhibited by Wee1 (CDK inhibiting kinase) by phosphorylation at tyrosine 15 position of cdc2. CAK (CDK activating kinasr) then phosphorylated CDK (cdc2) at threonine 161 position but M-CDK remains inactive still due to inhibitory tyrosine 15 phosphate. This tyr15 phosphate is then removed by cdc25 by dephosphorylation and leads to activation of M-CDK.

gladiator answered 2 years ago

Acetyl CoA carboxylase activity is regulated by hormone-controlled phosphorylation and dephosphorylation. a) Describe the effects of epinephrine...

Acetyl CoA carboxylase activity is regulated by hormone-controlled phosphorylation and dephosphorylation. a) Describe the effects of epinephrine on acetyl CoA carboxylase activity and fatty acid metabolism in the liver. b) Is this consistent with epinephrine’s effect on liver glycogen metabolism?

Describe two proteins phosphorylated by the M phase cyclin-dependent kinase (M-Cdk). What does the phosphorylation of...

Describe two proteins phosphorylated by the M phase cyclin-dependent kinase (M-Cdk). What does the phosphorylation of that protein cause?

Which of the following is not true about cyclin-dependent kinase (CDK): a. It’s present only during...

Which of the following is not true about cyclin-dependent kinase (CDK): a. It’s present only during the M phase of the cell cycle b. When CDK is combined with cyclin, the MPF (Mitosis Promoting Factor) formed initiates mitosis c. It’s a protein that controls other proteins using phosphate groups d. It’s present at all times during the cell cycle

What sorts of mutational changes could occur in a gene for a cyclin-dependent kinase might lead...

What sorts of mutational changes could occur in a gene for a cyclin-dependent kinase might lead to a cell becoming cancerous? Be as specific as you can as to what effect the mutational change would have on the kinase protein.

describe how an enzyme may be controlled by feedback inhibition

For an incident gamma-ray interacting with an inorganic scintillator, describe the interaction of the gamma-ray, how...

For an incident gamma-ray interacting with an inorganic scintillator, describe the interaction of the gamma-ray, how scintillation light is generated, how it is converted into an electrical signal, and how it is amplified.

1. Describe how emotions are a distributed, emergent property of interacting brain regions as opposed to...

1. Describe how emotions are a distributed, emergent property of interacting brain regions as opposed to arising from compartmentalized and specific brain regions. 2. Also, provide an example.

1. Regulation of protein activity by phosphorylation requires ________ activity. kinase ubiquitin protease phosphatase 20S proteasome 2....

1. Regulation of protein activity by phosphorylation requires ________ activity. kinase ubiquitin protease phosphatase 20S proteasome 2. Which of the following are substrates used by RNA polymerase in the process of transcription? DNA template ribonucleotie triphosphates deoxyribonucleotide triphosphates inorganic phosphates proteins 3. The ribosome is an enzyme complex made entirely of protein molecules. directs elongation of polypeptides. is organized into 2 subunits whose sizes are designated in Svedberg (S) units. is not used by cells that secrete large amounts of protein. is...

How is the level of cholesterol in the blood stream controlled? Describe and explain how two...

How is the level of cholesterol in the blood stream controlled? Describe and explain how two metabolic defects in humans that could produce an elevated blood cholesterol level. (4 points)

What is a tyrosine kinase receptor (RTK)? Describe how this type of receptor works. Once activated,...

What is a tyrosine kinase receptor (RTK)? Describe how this type of receptor works. Once activated, what kind of enzyme is needed to deactivate the receptor? Explain

Question