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Alterations in Immune Function How do type 1, 2, 3, and 4 hypersensitivity reactions differ according...

Alterations in Immune Function

How do type 1, 2, 3, and 4 hypersensitivity reactions differ according to mechanism of action?

What are the clinical features of the common immunodeficiency disorder?

Solutions

Expert Solution

  • Type I hypersensitivity reactions- B-cells are stimulated to produce IgE antibodies specific to an antigen. During sensitization, the IgE Antibodies bind to FCERI receptors on the surface of tissue mast cells and blood basophils.
  • Type II hypersensitivity reactions- this is a humoral response mediated by IgM or IgG that are produced against surface antigens on body cells.
  • Type III hypersensitivity reactions- it occurs when there is an excess of antigen, leading to small immune complexes being formed that fix compliment and are not cleared from the circulation.
  • Type IV hypersensitivity reactions- it is a common immune response that occurs through direct action of sensitized T cells when stimulated by contact with antigen.

The clinical features are

  • Frequent and recurrent infections
  • Sinus infections
  • Ear infections
  • Meningitis
  • Pneumonia
  • Bronchitis
  • Inflammation and infection of internal organs

Nightingale answered 2 years ago
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