Question

Solve these challenge question:

1.) The conversation of Glycinamide ribonucleotide to Formylglycinamide ribonucleotide utilizes a transformylase. Ture or False

2.) Which of these statements is FALSE about the production or activity of eicosanoid hormones?

	a.	Leukotrienes require an oxidoreductase to introduce a O2.
	b.	Aspirin and Aleve (naproxen) act as different types of inhibitors.
	c.	Aspirin is an irreversible inhibitor of COX isozymes acetylating a Ser.
	d.	Archidonate is a precursor for eicosanoids.
	e.	Eicosanoids are long-lived hormones that only affect cells far away.

Answer 1

1) True

Glycinamide ribonucleotide is converted into Formylglycinamide ribonucleotide by an enzyme GAR transformylase.

Conversion of Glycinamide ribonucleotide to Formylglycinamide ribonucleotide is an important reaction in de novo biosynthesis of purine. GAR transformylase use tetrahydrofolate (H4- THF) as a cofactor and catalyzes a nucleophilic substitution of the formyl group from N10-formyltetrahydrofolate (fTHF) to N1-(5-phospho-D-ribosyl)glycinamide (GAR) and form N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide (fGAR).

2. E. Eicosanoids are long-lived hormones that only affect cells far away (this is a false statement).

Eicosanoids are known as local hormone because it acts only cells close to its production site. work like hormones, but they do not like to travel. Eicosanoids are short-lived due to this they are unable to travel very far consequently can not affect cells far away.