8. What protein modification is commonly used to transduce signaling cascades?

Expert Solution

Ans-8.) Phosphorylation is the most common protein modification used to transduce signalling cascades.

* This is a type of covalent modification and is reversible in nature.

* Most commonly serine , tyrosine, threonine residues are involved involved in phosphorylation / dephosphorylation.

* Protein Kinases and Phosphatases are the enzymes which catalyze the reaction of phosphorylation and dephosphorylation of proteins, respectively.

* There are many types of protein kinases involved in signal transduction, all have same basic catalytic activity : they add a phosphate group to an amino acid in a target protein.

* Five groups of protein kinases are distinguished by the type of amino acid residue ,they target :

--- Serine / Threonine kinase

---tyrosine kinase

---Dual specificity kinase ( can phosphorylate either tyrosine or serine / threonine

--- Histidine kinase

---- Aspartate Kinase

gladiator answered 2 years ago

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