Question

Prepare an outline that identifies the major “non-immune” protective barriers against microbial invasion.

Answer 1

The innate immune response which is relatively rapid but non specific and thus not always effective

innate immune response usually begins with the physical barriers that prevent pathogens from entering into the body,destroy them after they enter

Barrier defences are part of the body most basic defensive mechanism

The different modes of barrier defences are associated with the external surface of the body,where pathogens may try to enter.

The primary barrier to the entrance of micro organisms into the body is the skin,sweat and other body secretions which lower the pH

lets discuss barrier defences and protective aspects briefly in a table:

Site	specific defense	Protective aspect
Skin	Epidermal surface	Keratinised cells of surface
Skin (sweat/secretions)	Sweat glands,sebaceous glands	Low pH
Oral cavity	Salivary glands	Lysozyme
Stomach	GI tract	Low pH
Mucosal surfaces	Mucosal epithelium	Non keratinised epithelial cells