The data below were reported for human immunoglobulin G (IgG) at 20ºC in dilute aqueous buffer....

The data below were reported for human immunoglobulin G (IgG) at 20ºC in dilute aqueous buffer.

M = 156,000 g/mol

D = 4.00 x 10^-11 m²/s

ν_B = 0.739 mL/g

Part A

Please use Stokes-Einstein diffusion models to calculate the frictional coefficient (f) of IgG.

Part B

Please use Stokes-Einstein diffusion models to calculate the frictional coefficient of an unhydrated molecule (f₀) of approximately the same size as IgG.

Solutions

Expert Solution

Frictional coefficient is the ratio of frictional force to the normal force which holds two moving objects together. The frictional coefficient can be determined either by Stoke's Law or by an expression which relates the frictional coefficient and the diffusion constant.

The frictional coefficient of a non-spherical molecule is always greater than that of a spherical molecule.

genius_generous answered 1 year ago

Next > < Previous

Related Solutions

For the reaction A(g) + 2B(g) → 2C(g) + 2D(g) the following data were collected at...

For the reaction A(g) + 2B(g) → 2C(g) + 2D(g) the following data were collected at constant temperature. Determine the correct rate law for this reaction. Trial Initial [A] (mol/L) Initial [B] (mol/L) Initial Rate (mol/(L·min) 1 0.125 0.200 7.25 2 0.375 0.200 21.75 3 0.250 0.400 14.50 4 0.375 0.400 21.75 Rate = k[A] [B] Rate = k[A]2 [B] Rate = k[A] [B]2 Rate = k[A]

For the reaction A(g) + B(g) + C(g) " D(g) the following data were obtained at 25°C....

For the reaction A(g) + B(g) + C(g) " D(g) the following data were obtained at 25°C. Exp’t Initial [A] (M) Initial [B] (M) Initial [C] (M) Initial Rate (mole∙L–1s–1) 1 0.0500 0.0500 0.0100 6.25 x 10–3 2 0.1000 0.0500 0.0100 1.25 x 10–2 3 0.1000 0.1000 0.0100 5.00 x 10–2 4 0.0500 0.0500 0.0200 6.25 x 10–3 5 0.2000 0.3000 0.3000 ????? Which choice gives correct kinetics information for this reaction? Which choice is closest to the rate constant for this...

CH4(g) + Cl2(g)  CH2Cl2(g) + 2 HCl(g) Use the data in the table below to...

CH4(g) + Cl2(g)  CH2Cl2(g) + 2 HCl(g) Use the data in the table below to calculate the standard enthalpy, ∆H˚, for the reaction above. Substance CH4(g) CH2Cl2(g) HCl(g) ∆Hf˚, kJ•mol-1 –74.6 –95.4 –92.3

The data shown below were collected for the following second-order reaction: Cl(g)+H2(g)→HCl(g)+H(g)Cl(g)+H2(g)→HCl(g)+H(g) Temperature (K)(K) Rate Constant...

The data shown below were collected for the following second-order reaction: Cl(g)+H2(g)→HCl(g)+H(g)Cl(g)+H2(g)→HCl(g)+H(g) Temperature (K)(K) Rate Constant (L/mol⋅s)(L/mol⋅s) 90 0.00357 100 0.0773 110 0.956 120 7.781 A)Use an Arrhenius plot to determine the activation barrier for the reaction B)Use an Arrhenius plot to determine the frequency factor for the reaction.

a. Calculate the pH of a buffer that is prepared by completely dissolving 0.0401 g of NH4Cl in exactly 25.0 ml of a 0.020 Molar aqueous NH3 solution.

a. Calculate the pH of a buffer that is prepared by completely dissolving 0.0401 g of NH4Cl in exactly 25.0 ml of a 0.020 Molar aqueous NH3 solution.b. What is the pH after 5.0 mL of 0.020 M NaOH solution is added to 0.020 L of this buffer?

1)The data below were collected for the following reaction: CH3Cl(g)+3Cl2(g)→CCl4(g)+3HCl(g) [CH3Cl](M) [Cl2](M) Initial Rate (M/s) 0.050...

1)The data below were collected for the following reaction: CH3Cl(g)+3Cl2(g)→CCl4(g)+3HCl(g) [CH3Cl](M) [Cl2](M) Initial Rate (M/s) 0.050 0.050 0.014 0.100 0.050 0.029 0.100 0.100 0.041 0.200 0.200 0.115 A Calculate the value of the rate constant, k. Express your answer using two significant figures. B What is the overall order of the reaction? Express your answer using two significant figures. 2) t (s) [A] (M) ln[A] 1/[A] 0.00 0.500 −0.693 2.00 20.0 0.389 −0.944 2.57 40.0 0.303 −1.19 3.30 60.0 0.236...

The data below represent the ages of drivers and the number of accidents reported for ...

The data below represent the ages of drivers and the number of accidents reported for each age group in Pennsylvania for a selected year. Use an excel spreadsheet to create a scatter plot and calculate the sample correlation coefficient. At the α = 0.10 level, test for a significant correlation between age and number of accidents. Age, x 16 17 18 19 20 21 Number of accidents, y 6605 8932 8506 7349 6458 5974

Using the below data: Mass (g) of copper gluconate: 1.0 g Mass (g) of wrapper: 0.6...

Using the below data: Mass (g) of copper gluconate: 1.0 g Mass (g) of wrapper: 0.6 g Mass (g) of wrapper + Cu: 0.9 g Mass (g) of Cu: 0.3 g Mass (g) of gluconate: 0.7 g 1. Determine the chemical formula of copper gluconate? 2. Calculate the percent composition of copper and the percent composition of gluconate in the compound copper gluconate? 3. Create a Experimental Chemical Formula:

Roller Paint Co. reported the following data for the month of September. There were no beginning...

Roller Paint Co. reported the following data for the month of September. There were no beginning inventories and all units were completed (no work in process). Total Cost Number of Units Unit Cost Manufacturing costs: Variable $465,000 30,000 $15.50 Fixed 210,000 30,000 7.00 Total $675,000 $22.50 Selling and administrative expenses: Variable $2.00 per unit sold Fixed $39,000 In the month of September, 28,000 of the 30,000 units manufactured were sold at a price of $80.00 per unit. Required: (a) Prepare...

The data below show the concentration of ABversus time for the following reaction: AB(g)→A(g)+B(g) A.Determine the...

The data below show the concentration of ABversus time for the following reaction: AB(g)→A(g)+B(g) A.Determine the order of the reaction. B.Determine the value of the rate constant. C.Predict the concentration of AB at 20 s . Time (s) [AB] (M) 0 0.950 50 0.459 100 0.302 150 0.225 200 0.180 250 0.149 300 0.128 350 0.112 400 0.0994 450 0.0894 500 0.0812

Subjects