The data below were reported for human immunoglobulin G (IgG) at 20ºC in dilute aqueous buffer....

The data below were reported for human immunoglobulin G (IgG) at 20ºC in dilute aqueous buffer.

M = 156,000 g/mol

D = 4.00 x 10^-11 m²/s

ν_B = 0.739 mL/g

Part A

Please use Stokes-Einstein diffusion models to calculate the frictional coefficient (f) of IgG.

Part B

Please use Stokes-Einstein diffusion models to calculate the frictional coefficient of an unhydrated molecule (f₀) of approximately the same size as IgG.

Expert Solution

Frictional coefficient is the ratio of frictional force to the normal force which holds two moving objects together. The frictional coefficient can be determined either by Stoke's Law or by an expression which relates the frictional coefficient and the diffusion constant.

The frictional coefficient of a non-spherical molecule is always greater than that of a spherical molecule.

genius_generous answered 2 years ago

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