Question

DRUG CHLORPROMAZINE (Please answer in question format)

1) Classification of this drug?

2) Is it a barbiturate or is it analgesic?

3) All other names used? All drugs in same class?

4) How is this made? Base structure of this drug, for example if its a morphine derivative show us the poppy, the molecule and where it is found?

5) Show drug that have similar chemical structure to the drug you are presenting. Show the actual chemical structure?

6) Pros and Cons to this drug?

7) Short term or long term side effects? Is it teratogenic, why?

8) Explain experimental methods and the study results of this study?

9) How the drug intracts with the body, pharmicokinetics & pharmacodynamics.

10) What is the half life of this drug?

11) What are the by products (if any) are these toxic?

12)How does it exert its function?

Answer 1

Drug Chlorpromazine

1) Classification of the drug - Phenothiazine; Antipsychotic

2) It has a sedative effect and used in combination mixture for an analesgic purpose.

3) Other names of the drug with the same class are

• Chlorderazin
• Chlorpromadas
• Aminarzine
• Largatil
• Contomin
• Thioridazine
• fenacitil

4).

Its molecular formula C₁₇H₁₉CIN₂S

It acts by blocking the dopamine receptors in the brain. It is also used for other therapeutic purposes such as nausea, vomiting, hiccups, anxiety, and other behavioral changes.

5)

Drug that has a similar chemical structure such as prochlorperazine

6)

Pros:

• Used for the treatment of schizophrenia and depression
• behavioral changes in children
• Used for an intractable cough.

Cons:

• It increases the risk in dementia-related condition.
• has pregnancy warnings
• Hepatotoxicity.

7).

Short-term side effects:

• drowsiness
• constipation
• impotence
• dry mouth
• blurred vision
• Changes in menstrual period
• Discharge or swelling from the best.

Long-term side effects:

• High fever and tremors
• rigid muscles
• pale skin, skin sores
• jaundice
• Difficulty in breathing and swallowing due to the stiff neck.
• Bruising or bleeding
• Confusion.

Studies show maternally toxic and malformations in animals and no evidence on human pregnancy. But warnings were given to avoid the using of the drug during the last trimester of pregnancy and avoid breastfeeding while using chlorpromazine.

8) A study conducted shows the drug used to treat the bipolar disorders in phase 4. Another study shows it is useful in the treatment of neonatal drug withdrawal syndrome.

9) It acts as an antiemetic and sedative. It has its major action on the central nervous system and also acts on multiple organs system. It has strong antiadrenergic activity and the weak anticholinergic activity. it is rapidly absorbed in the GI tract and metabolized in the liver and kidney.

10) The half-life of the drug 30 hours.

11) the byproducts of drug toxicities include

• agitation
• confusion
• convulsions
• Longtime sleepiness
• Intestinal blockage restlessness.

12) it exerts its function by blocking the dopamine receptors and act as an antagonist.